Relation of HLA-DRB1 to IgG4 autoantibody and cytokine production in muscle-specific tyrosine kinase myasthenia gravis (MuSK-MG)

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dc.contributor.authorÇebi, Merve
dc.contributor.authorDurmuş, Hacer
dc.contributor.authorYılmaz, Vuslat
dc.contributor.authorYentür, Sibel Penbe
dc.contributor.authorAysal, Fikret
dc.contributor.authorOflazer, Zehra Piraye
dc.contributor.authorParman, Yeşim Gülşen
dc.contributor.authorDeymeer, Feza
dc.contributor.authorSaruhan-Direskeneli, Güher
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:25Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:25Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractA small subset of myasthenia gravis (MG) patients develop autoantibodies against muscle-specific kinase (MuSK), which are predominantly of the immunoglobulin (Ig)G4 isotype. MuSK-MG is strongly associated with HLA-DRB1*14, HLA-DRB1*16 and HLA-DQB1*05. In this study, the possible effects of these HLA associations on MuSK IgG autoantibody or cytokine production were investigated. Samples from 80 MG patients with MuSK antibodies were studied. The disease-associated HLA types were screened in the DNA samples. The IgG1, IgG2, IgG3 and IgG4 titres of the MuSK antibodies and the levels of interleukin (IL)-4, IL-6, IL-17A and IL-10 were measured in the sera. Comparisons were made among the groups with or without HLA-DRB1*14, HLA-DRB1*16 or HLA-DQB1*05. The IgG4 titres of the MuSK antibodies were higher than those of the IgG1, IgG2 and IgG3 isotypes among the whole group of patients. DRB1*14 (+) DRB1*16 (–) patients had higher levels of IgG4 antibodies than those of DRB1*14 (–) DRB1*16 (+) patients. DRB1*14 (+) DRB1*16 (+) patients also had higher levels of IgG4 antibodies than those of DRB1*14 (–) DRB1*16 (+) and DRB1*14 (–) DRB1*16 (–) patients. Higher IL-10 and lower IL-17A levels were measured in DRB1*14 (+) DRB1*16 (–) patients than in DRB1*14 (–) DRB1*16 (–) patients. The higher IgG4 titres of MuSK autoantibodies in patients carrying HLA-DRB1*14 than those in the other patients suggest a role for HLA in the production of the antibodies. The differences in IL-10 and IL-17A support the role of DRB1 in the etiopathogenesis of this autoimmune response.
dc.description.sponsorshipIstanbul Universityen_US
dc.identifier.citationÇebi, M., Durmuş, H., Yılmaz, V., Yentür S. P., Aysal, F., Oflazer, Z. P. ve Saruhan Direskeneli, G. (2019). Relation of HLA-DRB1 to IgG4 autoantibody and cytokine production in muscle-specific tyrosine kinase myasthenia gravis (MuSK-MG). Clinical and Experimental Immunology, 197(2), 214-221. https://dx.doi.org/10.1111/cei.13302
dc.identifier.doi10.1111/cei.13302
dc.identifier.endpage221
dc.identifier.issn0009-9104
dc.identifier.issn1365-2249
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage214
dc.identifier.urihttps://hdl.handle.net/20.500.12511/764
dc.identifier.urihttps://dx.doi.org/10.1111/cei.13302
dc.identifier.volume197
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/116S317
dc.relation.ispartofClinical and Experimental Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectHLA
dc.subjectIgG Isotype
dc.subjectMuSK
dc.subjectMyasthenia Gravis
dc.titleRelation of HLA-DRB1 to IgG4 autoantibody and cytokine production in muscle-specific tyrosine kinase myasthenia gravis (MuSK-MG)
dc.typeArticle

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