Kidney-sparing surgery has equivalent oncological outcomes to radical nephroureterectomy for ureteral urothelial carcinoma

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dc.authorid0000-0003-0906-4417
dc.authorid0000-0002-6308-1763
dc.contributor.authorLiu, Kang
dc.contributor.authorZhao, Hongda
dc.contributor.authorNg, Chi Fai
dc.contributor.authorTeoh, Jeremy Yuen Chun
dc.contributor.authordel Pilar Laguna Pes, Maria
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.date.accessioned2024-06-06T10:34:04Z
dc.date.available2024-06-06T10:34:04Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractINTRODUCTION AND OBJECTIVE: Kidney-sparing surgery (KSS) for upper tract urothelial cancer (UTUC) has gained increasing interest recently. However, there is limited contemporary data regarding the role of KSS in ureteral urothelial carcinoma. Therefore, we investigated the survival outcomes of ureteral urothelial carcinoma after KSS from a large prospective international UTUC registry. METHODS: The Clinical Research Office of the Endourology Society-Urothelial Carcinomas of the Upper Tract (CROES-UTUC) Registry included UTUC patients who received KSS or radical nephroureterectomy (RNU) between 2014 and 2019. In this study, we included patients with ureteral UTUC only. Study outcomes included overall survival (OS), cancer-specific survival (CSS), upper tract recurrence-free survival (RFS), intravesical RFS, progression-free survival (PFS), and metastasis-free survival (MFS). Propensity score matching (PSM) was performed to balance the tumour features’ differences between groups. RESULTS: Of 391 patients with ureteral UTUC, 309 (79.0%) received RNU, and 82 (21.0%) received KSS by ureteroscopy with laser ablation (n=28) or segmental resection (n=54). After PSM, there were no differences in OS (p=0.525), CSS (p=0.487), upper tract RFS (p=0.147), intravesical RFS (p=0.989), PFS (p=0.617), and MFS (p=0.336) between KSS and RNU. Both ureteroscopic ablation and segmental resection had similar OS, CSS, intravesical RFS, PFS, and MFS with RNU. Proximal ureteral UTUC had worse OS and CSS outcomes than other tumour locations following segmental resection. CONCLUSIONS: In patients with ureteral UTUC, no significant differences in long-term survival outcomes were observed between KSS and RNU. Proximal ureteral UTUC had worse survival outcomes over other tumour locations following segmental resection.
dc.description.sponsorshipKARL STORZ
dc.identifier.citationLiu, K., Zhao, H., Ng, C.F., Teoh, J. Y. C., del Pilar Laguna Pes, M. ve de la Rosette, J. J. M. C. H. (2024). Kidney-sparing surgery has equivalent oncological outcomes to radical nephroureterectomy for ureteral urothelial carcinoma. Journal of Endourology, 38(9), 921-928. http://dx.doi.org/10.1089/end.2024.0061
dc.identifier.doi10.1089/end.2024.0061
dc.identifier.endpage928
dc.identifier.issn0892-7790
dc.identifier.issn1557-900X
dc.identifier.issue9
dc.identifier.pmid38756081
dc.identifier.scopus2-s2.0-85196086400
dc.identifier.scopusqualityQ1
dc.identifier.startpage921
dc.identifier.urihttp://dx.doi.org/10.1089/end.2024.0061
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12582
dc.identifier.volume38
dc.identifier.wosWOS:001242895600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthordel Pilar Laguna Pes, Maria
dc.institutionauthorde la Rosette, Jean J. M. C. H.
dc.language.isoen
dc.relation.ispartofJournal of Endourologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectKidney-Sparing Surgery
dc.subjectUpper Tract Urothelial Cancer
dc.subjectKSS
dc.subjectUTUC
dc.titleKidney-sparing surgery has equivalent oncological outcomes to radical nephroureterectomy for ureteral urothelial carcinoma
dc.typeArticle

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