The impact of prefertilization chronic mild stress on postnatal morphometric development

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dc.contributor.authorCankara, Neslihan
dc.contributor.authorMalas, Mehmet Ali
dc.contributor.authorEvcil, Emine Hilal
dc.contributor.authorDesdicio?lu, Kadir
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:34Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:34Z
dc.date.issued2012
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.descriptionWOS: 000298928200015
dc.descriptionPubMed ID: 21692689
dc.description.abstractObjective. The aim of the present study was to examine the effects of chronic mild stress (CMS) induced before the fertilization on gestational maternal weight, length of gestation, and postnatal morphometric development. Material and method. Study is carried out on 18 Wistar albino rats; six females in the stress group, six females in the control group, and six males to be used for mating. CMS was induced in rats of the stress group for 4 weeks, followed by a post-CMS waiting period of 5-weeks. Rats were left for mating at the end of the post-CMS period. Weight gain in pregnant rats was monitored and length of gestation and litter size were recorded in the stress and control groups. Growth parameters of pups pertaining to the body, cranium, thorax, and limbs were measured until week 11. Findings. Weight gained by pregnant rats in the stress group was less than the control group. Increases in mean morphometric parameters from day 0 to week 11 in the stress group were less than the control group (p < 0.05). Furthermore, when developmental parameters at weeks 7, 9, and 11 were compared between genders, females in the stress group were found more affected than males (p < 0.05). Conclusion. CMS sustained before fertilization has a negative effect on gestational maternal weight and postnatal morphometric development of pups, more prominently in females.
dc.identifier.citationCankara, N., Malas, M. A. H., Evcil, E. H. ve Desdicio?lu, K. (2012). The impact of prefertilization chronic mild stress on postnatal morphometric development. Journal of Metarnal - Fetal & Neonatal Medicine, 25(2), 165-173. https://dx.doi.org/10.3109/14767058.2011.566947
dc.identifier.doi10.3109/14767058.2011.566947
dc.identifier.endpage173
dc.identifier.issn1476-7058
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage165
dc.identifier.urihttps://dx.doi.org/10.3109/14767058.2011.566947
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3193
dc.identifier.volume25
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcare
dc.relation.ispartofJournal of Metarnal - Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChronic Mild Stress
dc.subjectMorphometry
dc.subjectDevelopmental Anatomy
dc.subjectRat
dc.subjectGestation
dc.titleThe impact of prefertilization chronic mild stress on postnatal morphometric development
dc.typeArticle

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