Aloe vera-based antibacterial porous sponges for wound dressing applications

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dc.authorid0000-0001-8267-0435
dc.contributor.authorTamahkar, Emel
dc.contributor.authorÖzkahraman, Bengi
dc.contributor.authorÖzbaş, Zehra
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorYarımçan, Filiz
dc.contributor.authorBoran, Filiz
dc.contributor.authorBal Öztürk, Ayça
dc.date.accessioned2021-10-07T09:42:53Z
dc.date.available2021-10-07T09:42:53Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractThe antibacterial sponges with high macroporosity, high interconnectivity and high biocompatibility is a significant concern for wound healing applications. In this work, novel Aloe vera (AV) based sponges were developed via subsequent lyophilization with further chemical crosslinking throughout the double network sponges. Single network was composed of gelatin-sodium alginate (G-SA) while the double network using gelatin-sodium alginate- sodium hyaluronate (G-SA-HA) was produced with the addition of hyaluronic acid solution into the gelatin-sodium alginate matrix. Lastly, Aloe vera as the bioactive agent was fabricated throughout the gelatin-sodium alginate-sodium hyaluronate matrix. The AV-based sponges demonstrated large pores with high interconnectivity. The swelling degree of the AV-based sponges were higher than that of G-SA and G-SA-HA sponges. The release of AV from the sponges reached an equilibrium value after 24 h showing a more controlled release at pH 5.5 than at pH 7.4. AV-based sponges showed antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Streptococcus pneumoniae and Bacillus cereus and displayed any cytotoxicity against Mesenchymal stem cells.
dc.description.sponsorshipHitit University ; Hitit University Scientific and Tecnical Application and Research Centeren_US
dc.identifier.citationTamahkar, E., Özkahraman, B., Özbaş, Z., İzbudak, B., Yarımçan, F., Boran, F. ... Bal Öztürk, A. (2021). Aloe vera-based antibacterial porous sponges for wound dressing applications. Journal of Porous Materials, 28(3), 741-750. https://dx.doi.org/10.1007/s10934-020-01029-1
dc.identifier.doi10.1007/s10934-020-01029-1
dc.identifier.endpage750
dc.identifier.issn1380-2224
dc.identifier.issn1573-4854
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage741
dc.identifier.urihttps://dx.doi.org/10.1007/s10934-020-01029-1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8385
dc.identifier.volume28
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Porous Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAloe Vera
dc.subjectAntibacterial Sponge
dc.subjectHydrogel
dc.subjectWound Dressings
dc.titleAloe vera-based antibacterial porous sponges for wound dressing applications
dc.typeArticle

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