The neuroprotective effect of syringic acid on spinal cordischemia/reperfusion injury in rats

Basit Öğe Kaydı
dc.contributor.authorTokmak, Mehmet
dc.contributor.authorYüksel, Yasemin
dc.contributor.authorŞehitoğlu, Müşerref Hilal
dc.contributor.authorGüven, Mustafa
dc.contributor.authorAkman, Tarık
dc.contributor.authorBozkurt Aras, Adem
dc.contributor.authorCoşar, Murat
dc.contributor.authorAbbed, Khalid
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:26Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:26Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.descriptionWOS: 000360847200026
dc.descriptionPubMed ID: 25903968
dc.description.abstractAcute arterial occlusions via different vascular pathologies are the main causes of spinal cord ischemia. We investigated neuroprotective effects of syringic acid on spinal cord ischemia injury in rats. Rats were divided into four groups: (I) sham-operated control rats, (II) spinal cord ischemia group, (III) spinal cord ischemia group performed syringic acid, and (IV) spinal cord ischemia group performed methylprednisolone intraperitoneally. Spinal cord ischemia was performed by the infrarenal aorta cross-clamping model. The spinal cord was removed after the procedure. The biochemical and histopathological changes were observed within the samples. Functional assessment was performed for neurological deficit scores. A significant decrease was seen in malondialdehyde levels in group III as compared to group II (P < 0.05). Besides these, nuclear respiratory factor-1 and superoxide dismutase activity of group III were significantly higher than group II (P < 0.05). In histopathological samples, when group III was compared with group II, there was a significant decrease in numbers of apoptotic neurons (P < 0.05). In immunohistochemical staining, BECN1 and caspase-3-immunopositive neurons were significantly decreased in group III compared with group II (P < 0.05). The neurological deficit scores of group III were significantly higher than group II at twenty-fourth hour of ischemia (P < 0.05). Our study revealed that syringic acid pretreatment in spinal cord ischemia/reperfusion reduced oxidative stress and neuronal degeneration as a neuroprotective agent. Ultrastructural studies are required for syringic acid to be developed as a promising therapeutic agent to be utilized for human spinal cord ischemia in the future.
dc.identifier.citationTokmak, M., Yüksel, Y., Şehitoğlu, M. H., Güven, M., Akman, T., Bozkurt Aras, A. ... Abbed, K. (2015). The neuroprotective effect of syringic acid on spinal cord ıschemia/reperfusion injury in rats. Inflammation, 38(5), 1969-1978. https://dx.doi.org/10.1007/s10753-015-0177-2
dc.identifier.doi10.1007/s10753-015-0177-2
dc.identifier.endpage1978
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue5
dc.identifier.scopusqualityQ2
dc.identifier.startpage1969
dc.identifier.urihttps://dx.doi.org/10.1007/s10753-015-0177-2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2703
dc.identifier.volume38
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectSpinal Cord ischemia
dc.subjectSyringic Acids
dc.subjectMethylprednisolone
dc.subjectReperfusion
dc.subjectMalondialdehyde
dc.subjectNuclear Respiratory Factor 1
dc.subjectSuperoxide Dismutase
dc.titleThe neuroprotective effect of syringic acid on spinal cordischemia/reperfusion injury in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
tokmak, mehmet-2015.pdf
Boyut:
800.79 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu