Histologic and histomorphometric comparison of bone regeneration between bone morphogenetic protein-2 and platelet-derived growth factor-BB in experimental groups

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dc.contributor.authorGüven, Gökhan
dc.contributor.authorGültekin, Bahattin Alper
dc.contributor.authorGüven Şenol, Gamze
dc.contributor.authorGüzel, Elif
dc.contributor.authorFurat, Selenay
dc.contributor.authorErsanlı, Selim
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:57:53Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:57:53Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Ana Bilim Dalı
dc.descriptionWOS: 000376992200102
dc.descriptionPubMed ID: 27092911
dc.description.abstractEfficacy of recombinant human bone morphogenetic protein-2 (rhBMP-2) and recombinant human platelet-derived growth factor-BB (rhPDGF-BB) delivered via absorbable collagen sponge (ACS) on bone formation was evaluated in guinea pig tibias. Three-millimeter-circular bone tibia defects were created in 24 guinea pigs assigned randomly to 4 groups according to the following defect filling materials: ACS only, rhBMP-2_ACS, rhPDGF-BB_ACS, or empty. New bone formation was evaluated histologically and histomorphometrically at 15 (early healing) and 45 days (late healing). Mean new bone per total defect area ratio was 0.73, 0.57, 0.43, and 0.42 in rhBMP-2_ACS, rhPDGF-BB_ACS, ACS only, and empty groups at early healing, respectively. During early healing, significantly more new bone formation was observed in rhBMP-2_ACS and rhPDGF-BB_ACS groups than in the control groups. New bone formation was significantly higher with rhBMP-2_ACS than with rhPDGF-BB_ACS. Mean new bone per total defect area ratio was 0.81, 0.86, 0.74, and 0.75 in the rhBMP2_ACS, rhPDGF-BB_ACS, ACS only, and empty groups at late healing, respectively. During late healing, new bone formation was significantly higher in the rhPDGF-BB_ACS group relative to both control groups, but the results did not differ significantly from those in the rhBMP-2_ACS group. New bone formation in the rhBMP2_ACS group did not change significantly between the healing periods. In the rhPDGF-BB_ACS group, however, new bone formation was significantly higher in the late healing period. Both growth factors accelerated new bone formation in the early healing period. Although rhBMP-2 was more effective in the early healing period, the effects of rhPDGF-BB were longer lasting.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University [2013-10]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordination Unit of Istanbul University (Project 2013-10).en_US
dc.identifier.citationGüven, G., Gültekin, B. A., Güven Şenol, G., Güzel, E., Furat, S. ve Ersanlı, S. (2016). Histologic and histomorphometric comparison of bone regeneration between bone morphogenetic protein-2 and platelet-derived growth factor-BB in experimental groups. Journal Of Craniofacial Surgery, 27(3), 805-809. https://dx.doi.org/10.1097/SCS.0000000000002560
dc.identifier.doi10.1097/SCS.0000000000002560
dc.identifier.endpage809
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue3
dc.identifier.scopusqualityQ3
dc.identifier.startpage805
dc.identifier.urihttps://dx.doi.org/10.1097/SCS.0000000000002560
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3065
dc.identifier.volume27
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal Of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAbsorbable Collagen Sponge
dc.subjectBone Regeneration
dc.subjectGuinea Pig
dc.subjectRHBMP-2
dc.subjectRhPDGF-BB
dc.titleHistologic and histomorphometric comparison of bone regeneration between bone morphogenetic protein-2 and platelet-derived growth factor-BB in experimental groups
dc.typeArticle

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