Is there any association between EBV infection and carotid artery stenosis?

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dc.authorid0000-0001-9338-8152
dc.authorid0000-0001-6643-9364
dc.contributor.authorBeyaz, Metin Onur
dc.contributor.authorAgaçfidan, Ali
dc.contributor.authorÖnel, Mustafa
dc.contributor.authorÖztaş, Didem Melis
dc.contributor.authorErdinç, İbrahim
dc.contributor.authorRodoplu, Orhan
dc.contributor.authorMeriç, Mert
dc.contributor.authorÜnal, Orçun
dc.contributor.authorConkbayır, Cenk
dc.contributor.authorUğurlucan, Murat
dc.date.accessioned2021-12-31T07:22:18Z
dc.date.available2021-12-31T07:22:18Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kalp ve Damar Cerrahisi Ana Bilim Dalı
dc.description.abstractObjective: Atherosclerosis is the mainly etiologic factor of coronary artery disease, carotid artery disease and peripheral artery disease. In our study, we aimed to show the presence and effect of Epstein-Barr virus (EBV) on the carotid artery stenosis leading chronic inflammatory process by producing pro-inflammatory cytokines and causing atherosclerosis. Material and methods: Between April 2017 and April 2018, thirty-six patients, who underwent carotid endarterectomy at Department of Cardiovascular Surgery, Istanbul University Istanbul Medical Faculty, are included in this study upon their consent. Each voluntary patient was initially recorded for age, sex, height and weight. Among 36 patients included in the study, 58.3% (n = 21) were male and 41.7% (n = 15) were female. The comorbidities such as hypertension, diabetes mellitus were considered. Results: There was not significant difference in EBV (DNA) positivity according to hyperlipidemia presence, sex, and age factors. However, the EBV (DNA) positivity was higher in the patients with co-morbidities such as hypertension and diabetes mellitus; no significant difference was detected. EBV (DNA) positivity in patients with bilateral carotid artery stenosis was 42.1% and it was 0% in patients without bilateral carotid artery stenosis (p: 0,002). The EBV (DNA) positivity was significantly higher in patients with bilateral carotid artery stenosis Conclusion: We believe that our significantly high EBV (DNA) rates in the patients with bilateral carotid artery stenosis may encourage the studies that claim the role of viral etiology on atherosclerosis, however, further studies are needed.
dc.identifier.citationBeyaz, M. O., Agaçfidan, A., Önel, M., Öztaş, D. M., Erdinç, İ., Rodoplu, O. ... Uğurlucan, M. (2021). Is there any association between EBV infection and carotid artery stenosis? Cor et Vasa, 63(5), 535-539. https://doi.org/10.33678/cor.2021.101
dc.identifier.doi10.33678/cor.2021.101
dc.identifier.endpage539
dc.identifier.issn0010-8650
dc.identifier.issn1803-7712
dc.identifier.issue5
dc.identifier.scopusqualityQ4
dc.identifier.startpage535
dc.identifier.urihttps://doi.org/10.33678/cor.2021.101
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8743
dc.identifier.volume63
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCzech Society of Cardiology Z.S
dc.relation.ispartofCor et Vasaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAtherosclerosis
dc.subjectCarotid Artery Stenosis
dc.subjectEBV
dc.subjectViral Etiology
dc.titleIs there any association between EBV infection and carotid artery stenosis?
dc.typeArticle

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