Lipemia retinalis following FLAG-Ida protocol in an 11-year-old patient with acute myeloid leukemia

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dc.contributor.authorKaplan Koruk, Reyhan Hazal
dc.contributor.authorKocabora, Mehmet Selim
dc.contributor.authorKaraman Erdur, Sevil
dc.contributor.authorYaman, Yöntem
dc.date.accessioned2025-07-22T09:33:47Z
dc.date.available2025-07-22T09:33:47Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction: We report a case of early-onset lipemia retinalis secondary to the FLAG-Ida protocol in the treatment of acute myeloid leukemia (AML) in an 11-year-old girl. Case Report: An 11-year-old patient, diagnosed with AML at four months old, experienced a relapse and was treated with the FLAG-Ida protocol (fludarabine, idarubicin, granulocyte-colony stimulating factor, and high-dose cytarabine). Prior to allogeneic stem cell transplantation, she underwent a pre-transplantation eye examination. The patient exhibited normal visual acuity in both eyes. Fundus examination revealed cream-white retinal vessels and a salmon-pink retina, indicative of grade 3 lipemia retinalis. Laboratory tests, normal before treatment initiation, showed significantly elevated serum cholesterol (727.6 mg/dL) and triglyceride (6015.6 mg/dL) levels post-treatment. After receiving fenofibrate, these levels decreased markedly, and the retinal vessels normalized on follow-up fundus examination. Conclusion: Lipemia retinalis, characterized by creamy-white retinal vessels resulting from hypertriglyceridemia, can develop as a secondary condition to chemotherapy. Early detection and treatment of hyperlipidemia are crucial to prevent severe ocular and systemic complications. This case highlights the importance of monitoring lipid levels and conducting thorough ophthalmologic examinations in patients undergoing chemotherapy.
dc.identifier.citationKaplan Koruk, R. H., Kocabora, M. S., Karaman Erdur, S. ve Yaman, Y. (2025). Lipemia retinalis following FLAG-Ida protocol in an 11-year-old patient with acute myeloid leukemia. European Journal of Ophthalmology, 35(1). http://dx.doi.org/10.1177/11206721241287347
dc.identifier.doi10.1177/11206721241287347
dc.identifier.issn1120-6721
dc.identifier.issn1724-6016
dc.identifier.issue1
dc.identifier.pmid39340315
dc.identifier.scopus2-s2.0-85205370946
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1177/11206721241287347
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13012
dc.identifier.volume35
dc.identifier.wosWOS:001321258700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKocabora, Mehmet Selim
dc.institutionauthorKaraman Erdur, Sevil
dc.institutionauthorYaman, Yöntem
dc.institutionauthorid0000-0001-5335-3860
dc.institutionauthorid0000-0001-9829-7268
dc.institutionauthorid0000-0002-9710-8653
dc.language.isoen
dc.relation.ispartofEuropean Journal of Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPharmacology
dc.subjectHypercholesterolemia
dc.subjectHypertriglyceridemia
dc.subjectLeukemia
dc.titleLipemia retinalis following FLAG-Ida protocol in an 11-year-old patient with acute myeloid leukemia
dc.typeArticle

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