Are the leading drugs against Staphylococcus aureus really toxic to cartilage?

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dc.authorid0000-0001-9052-4411
dc.authorid0000-0002-7794-9308
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorİşyar, Mehmet
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorBilir, Bülent
dc.contributor.authorŞirin, Duygu Y.
dc.contributor.authorÇakmak, Selami
dc.contributor.authorMahiroğulları, Mahir
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:18Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:18Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.descriptionMiddle East Respiratory Syndrome Coronavirus (MERS-CoV) Research Initiative Workshop -- SEP 09-10, 2015 -- Riyadh, SAUDI ARABIA
dc.descriptionWOS: 000376463900010
dc.descriptionPubMed ID: 26603270
dc.description.abstractMany studies have shown that the toxic effects of local antibiotics on bone and cartilage limit orthopedic surgeons. In this study, we evaluated three antibacterial agents used locally to treat highly mortal and morbid diseases in the field of orthopedics, such as septic arthritis. Are vancomycin, teicoplanin, and linezolid, which are archenemies of Staphylococcus aureus, really toxic to chondrocytes? The purpose of the study was to investigate the effects of antibiotics, which are used against S. aureus, on human chondrocytes in vitro. Primary cell cultures obtained from gonarthrosis patients were divided into two main groups. One of these groups was designated as the control chondrocyte culture. The other group was divided into three subgroups, and each group was exposedto vancomycin, teicoplanin, or linezolid. Cell culture samples were characterized by immunophenotyping following incubation with the three different antibiotics. Before and after the agents were administered, the cultures were subjected to inverted and environmental scanning electron microscopy. The number of live cells and the proliferation rate were monitored with the MTT-assay. We found that vancomycin, teicoplanin, and linezolid do not have chondrotoxic effects. Vancomycin, teicoplanin, and linezolid had no chondrotoxic activity during in vitro culture, which supports the argument that these agents can safely be used in orthopedic surgery, especially against methicillin-resistant S. aureus agents.
dc.identifier.citationDoğan, M., İşyar, M., Yılmaz, İ., Bilir, B., Şirin, D. Y., Çakmak, S. ... Mahiroğulları, M. (2016). Are the leading drugs against Staphylococcus aureus really toxic to cartilage? Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Research Initiative Workshop içinde (251-258. ss.). Riyadh, Saudi Arabia, September 09-10, 2015. https://dx.doi.org/10.1016/j.jiph.2015.10.004
dc.identifier.doi10.1016/j.jiph.2015.10.004
dc.identifier.endpage258
dc.identifier.issn1876-0341
dc.identifier.issn1876-035X
dc.identifier.issue3
dc.identifier.scopusqualityN/A
dc.identifier.startpage251
dc.identifier.urihttps://dx.doi.org/10.1016/j.jiph.2015.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3144
dc.identifier.volume9
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofMiddle East Respiratory Syndrome Coronavirus (MERS-CoV) Research Initiative Workshopen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectChondrocyte
dc.subjectLinezolid
dc.subjectTeicoplanin
dc.subjectToxicity
dc.subjectVancomycin
dc.titleAre the leading drugs against Staphylococcus aureus really toxic to cartilage?
dc.typeConference Object

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