Evaluation of a less invasive cochlear implant surgery in OPA1 mutations provoking deafblindness

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dc.contributor.authorTekin, Ahmet Mahmut
dc.contributor.authorBaelen, Hermine
dc.contributor.authorHeuninck, Emilie
dc.contributor.authorBayazıt, Yıldırım Ahmet
dc.contributor.authorMertens, Griet
dc.contributor.authorRompaey, Vincent van
dc.contributor.authorHeyning, Paul van de
dc.contributor.authorTopsakal, Vedat
dc.date.accessioned2023-04-07T11:34:49Z
dc.date.available2023-04-07T11:34:49Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun Boğaz Hastalıkları Ana Bilim Dalı
dc.description.abstractCochlear implantation (CI) for deafblindness may have more impact than for non-syndromic hearing loss. Deafblind patients have a double handicap in a society that is more and more empowered by fast communication. CI is a remedy for deafness, but requires revision surgery every 20 to 25 years, and thus placement should be minimally invasive. Furthermore, failed reimplantation surgery will have more impact on a deafblind person. In this context, we assessed the safety of minimally invasive robotically assisted cochlear implant surgery (RACIS) for the first time in a deafblind patient. Standard pure tone audiometry and speech audiometry were performed in a patient with deafblindness as part of this robotic-assisted CI study before and after surgery. This patient, with an optic atrophy 1 (OPA1) (OMIM#165500) mutation consented to RACIS for the second (contralateral) CI. The applicability and safety of RACIS were evaluated as well as her subjective opinion on her disability. RACIS was uneventful with successful surgical and auditory outcomes in this case of deafblindness due to the OPA1 mutation. RACIS appears to be a safe and beneficial intervention to increase communication skills in the cases of deafblindness due to an OPA1 mutation. The use of RACIS use should be widespread in deafblindness as it minimizes surgical trauma and possible failures.
dc.identifier.citationTekin, A. M., Baelen, H., Heuninck, E., Bayazıt, Y. A., Mertens, G., Rompaey, V. ... Topsakal, V. (2023). Evaluation of a less invasive cochlear implant surgery in OPA1 mutations provoking deafblindness. Genes, 14(3). https://dx.doi.org/10.3390/genes14030627
dc.identifier.doi10.3390/genes14030627
dc.identifier.issn2073-4425
dc.identifier.issue3
dc.identifier.pmid36980899
dc.identifier.scopus2-s2.0-85151109091
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.3390/genes14030627
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10824
dc.identifier.volume14
dc.identifier.wos000958229100001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBayazıt, Yıldırım Ahmet
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofGenesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectSensorineural Hearing Loss
dc.subjectOtogenetics
dc.subjectGenetic Deafness
dc.subjectHereditary Hearing Impairment
dc.subjectDeafblindness
dc.subjectGenetic Analyses on Sensorineural Hearing Loss
dc.subjectImage Guided Surgery
dc.subjectRobot Assisted Cochlear Implantation Surgery
dc.titleEvaluation of a less invasive cochlear implant surgery in OPA1 mutations provoking deafblindness
dc.typeArticle

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