Advanced oxidation protein products and ischaemia-modified albumin in obstructive sleep apnea

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dc.contributor.authorÖzben, Serkan
dc.contributor.authorHüseyinoğlu, Nergiz
dc.contributor.authorHanikoğlu, Ferhat
dc.contributor.authorGüvenc, Tolga Sinan
dc.contributor.authorYıldırım, Binnaz Zeynep
dc.contributor.authorÇört, Ayşegül
dc.contributor.authorÖzdem, Sebahat
dc.contributor.authorÖzben, Tomris
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:52:27Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:52:27Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000344525600003
dc.descriptionPubMed ID: 25223839
dc.description.abstractBackgroundSeveral studies have shown that obstructive sleep apnea increases incidence of cardiovascular morbidity and mortality. The high systemic oxidative stress in obstructive sleep apnea has been considered as a major pathogenic mechanism leading to cardiovascular disease. Oxidative stress-related lipid and DNA oxidation in obstructive sleep apnea have been reported in the previous studies. In contrast, there is limited and contradictory information regarding protein oxidation in obstructive sleep apnea patients such as ischaemia-modified albumin and advanced oxidation protein products. Therefore, we aimed to investigate plasma ischaemia-modified albumin and advanced oxidation protein products and their correlation with total oxidative status and total antioxidative capacity in the obstructive sleep apnea patients. MethodsPlasma ischaemia-modified albumin, advanced oxidation protein products, total oxidative status and total antioxidative capacity were measured in 25 healthy volunteers and 59 obstructive sleep apnea patients diagnosed with polysomnography. ResultsPlasma total antioxidative capacity was significantly lower (P=0012) and total oxidative status was significantly higher (P<0001) in the patients compared to the controls demonstrating increased oxidative stress in the patients. Plasma advanced oxidation protein products were significantly higher in the patients than the controls (P=0024). Plasma ischaemia-modified albumin levels were not statistically different between the obstructive sleep apnea patients and controls (P=074). ConclusionsWe conclude that high systemic oxidative stress in obstructive sleep apnea is reflected by increased advanced oxidation protein products without causing an increase in ischaemia-modified albumin.
dc.description.sponsorshipAkdeniz Universityen_US
dc.description.sponsorshipThe study was supported by a research grant from Akdeniz University Research Funds.en_US
dc.identifier.citationÖzben, S., Hüseyinoğlu, N., Hanikoğlu, F., Güvenc, T. S., Yıldırım, B. Z., Çört, A. ... Özben, T. (2014). Advanced oxidation protein products and ischaemia-modified albumin in obstructive sleep apnea. European Journal of Clinical Investigation, 44(11), 1045-1052. https://dx.doi.org/10.1111/eci.12338
dc.identifier.doi10.1111/eci.12338
dc.identifier.endpage1052
dc.identifier.issn0014-2972
dc.identifier.issn1365-2362
dc.identifier.issue11
dc.identifier.scopusqualityQ1
dc.identifier.startpage1045
dc.identifier.urihttps://dx.doi.org/10.1111/eci.12338
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2403
dc.identifier.volume44
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofEuropean Journal of Clinical Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAdvanced Oxidation Protein Products
dc.subjectIschaemia-Modified Albumin
dc.subjectObstructive Sleep Apnea
dc.subjectOxidative Stress
dc.subjectTotal Antioxidative Capacity
dc.subjectTotal Oxidative Status
dc.titleAdvanced oxidation protein products and ischaemia-modified albumin in obstructive sleep apnea
dc.typeArticle

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