Determination of the retinal toxicity of intravitreal colistin in rabbit eyes

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dc.authorid0000-0002-6408-2709
dc.authorid0000-0001-9829-7268
dc.authorid0000-0002-8851-6559
dc.authorid0000-0001-8954-5055
dc.authorid0000-0002-8047-5553
dc.contributor.authorÖzbek, Merve
dc.contributor.authorOdabaşı, Mahmut
dc.contributor.authorKaraman Erdur, Sevil
dc.contributor.authorŞentürk, Fevzi
dc.contributor.authorÖzsütçü, Mustafa
dc.contributor.authorAras, Cengiz
dc.date.accessioned2021-11-02T11:35:39Z
dc.date.available2021-11-02T11:35:39Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose To determine the possible adverse effects and safe dose range of intravitreal colistin, an antibiotic, after its intravitreal application. Methods Twenty eyes of 20 adult male and female New Zealand white rabbits were selected. Various concentrations of colistin were prepared. In each rabbit, 0.1 mL of colistin solution or saline solution was injected intravitreally into the right eye. Electroretinographic recordings were taken before and 2 weeks after injection. Histopathological examination was made using a light microscope following enucleation and fixation procedures. In histopathologic cross-sections, the differences between drug-injected eyes and control eyes were evaluated. Results Electroretinographic examination showed a decrease of 30% as a significant value in the a and b wave amplitudes of the rabbits that injected 400 mu g/0.1 ml and higher concentrations. Histological examination revealed histiocytic infiltration, histiocytic vacuoles, inflammation, and retinal degeneration in rabbit eyes given 400 mu g/0.1 ml, 800 mu g/0.1 ml, and 1.6 mg/0.1 ml concentrations of colistin. Conclusion Based on our findings, the safe concentration of colistin is 0.2 mg/0.1 ml. Administration of 0.4 mg/0.1 ml was associated with cataract development, electrophysiological depression, and pathological changes in retinal layers.
dc.identifier.citationÖzbek, M., Odabaşı, M., Karaman Erdur, S., Şentürk, F., Özsütçü, M. ve Aras, C. (2021). Determination of the retinal toxicity of intravitreal colistin in rabbit eyes. Cutaneous and Ocular Toxicology, 40(4), 300-304. https://dx.doi.org/10.1080/15569527.2021.1945617
dc.identifier.doi10.1080/15569527.2021.1945617
dc.identifier.endpage304
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue4
dc.identifier.scopusqualityQ3
dc.identifier.startpage300
dc.identifier.urihttps://dx.doi.org/10.1080/15569527.2021.1945617
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8545
dc.identifier.volume40
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectColistin
dc.subjectElectroretinography
dc.subjectEndophthalmitis
dc.subjectIntravitreal Injection
dc.subjectRetinal Toxicity
dc.titleDetermination of the retinal toxicity of intravitreal colistin in rabbit eyes
dc.typeArticle

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