Six miRNA expressions in the saliva of smokers and non-smokers with periodontal disease

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dc.authorid0000-0001-5166-2109
dc.contributor.authorÖngöz Dede, Figen
dc.contributor.authorGökmenoğlu, Ceren
dc.contributor.authorTürkmen, Emrah
dc.contributor.authorBozkurt Doğan, Şeyma
dc.contributor.authorAyhan, Burhanettin Sertaç
dc.contributor.authorYıldırım, Kubilay
dc.date.accessioned2023-09-18T12:00:36Z
dc.date.available2023-09-18T12:00:36Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractBackgroundIt has been stated that microRNA (miRNA) plays an important role in development, homeostasis, and immune functions, and abnormal miRNA expression may cause faster disease progression. ObjectiveThe aim of this study was to determine miR-203, miR-142-3p, miR-146a, miR-146b, miR-155, and miR-29b gene expressions in the saliva of smokers and non-smokers with the periodontal disease before and after non-surgical periodontal therapy (NSPT). MethodsA total of 90 individuals, 30 with periodontitis, 30 with gingivitis, and 30 periodontally healthy (control group), were included. These three groups were divided into subgroups as smoking and non-smoking individuals, with 15 people in each group. NSPT was applied to patients with periodontitis and gingivitis. Saliva samples and clinical parameters were obtained at baseline and repeated 6 weeks after NSPT. ResultsSaliva miR-203, miR-142-3p, miR-146a, miR-146b, and miR-155 gene expressions were significantly upregulated in patients with periodontal disease compared to the control group both in smokers and non-smokers, and also these miRNAs' gene expressions were significantly higher in the periodontitis group than in the gingivitis group at baseline (p < .05). A significant increase in saliva miR-142-3p expression was detected in all groups of smokers compared to non-smokers (p < .05). Although there was a decrease in salivary miRNAs gene expressions with the treatment, it was not statistically significant (p > .05). ConclusionsThese results suggest that salivary miR-146a, miR-146b, miR142-3p, miR-155, and miR-203 gene expressions increased with the progression of periodontal disease, but unchanged after periodontal treatment. Moreover, smoking may contribute to an increase in the levels of salivary miR-142-3p in the periodontal health and disease.
dc.identifier.citationÖngöz Dede, F., Gökmenoğlu, C., Türkmen, E., Bozkurt Doğan, Ş., Ayhan, B. S. ve Yıldırım, K. (2023). Six miRNA expressions in the saliva of smokers and non-smokers with periodontal disease. Journal of Periodontal Research, 58(1), 195-203. https://dx.doi.org/10.1111/jre.13081
dc.identifier.doi10.1111/jre.13081
dc.identifier.endpage203
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue1
dc.identifier.pmid36495003
dc.identifier.scopus2-s2.0-85144082364
dc.identifier.scopusqualityQ1
dc.identifier.startpage195
dc.identifier.urihttps://dx.doi.org/10.1111/jre.13081
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11449
dc.identifier.volume58
dc.identifier.wos000912470600001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTürkmen, Emrah
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/318S106
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectGingivitis
dc.subjectmiRNA
dc.subjectPeriodontal Therapy
dc.subjectPeriodontitis
dc.subjectSmoking
dc.titleSix miRNA expressions in the saliva of smokers and non-smokers with periodontal disease
dc.typeArticle

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