Intracavernosal mesenchymal stem cell therapy in ischaemic priapism: an experimental study

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dc.contributor.authorKılıç, Enes
dc.contributor.authorÇolakerol, Aykut
dc.contributor.authorTemiz, Mustafa Zafer
dc.contributor.authorYentur, Serhat
dc.contributor.authorBaşağa, Yaşar
dc.contributor.authorTavukçu, Hasan Hüseyin
dc.contributor.authorKandıralı, İsmail Engin
dc.date.accessioned2025-10-13T11:36:43Z
dc.date.available2025-10-13T11:36:43Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractIntroduction: The most common form of priapism is ischaemic and its prevalence in men has increased in recent years as a result of intracavernosal drug use. Currently, there is no approved specific treatment for ischaemic priapism other than cavernosal aspiration, which can only provide detumescence. This study aims to evaluate the efficacy of intracavernosal mesenchymal stem cell (MSC) therapy in an ischaemic priapism model. Material and methods: Thirty male Wistar albino rats were divided into three groups: sham (n = 6), priapism (n = 12) and priapism + MSC treatment (n = 12). The experimental groups were also divided into 1 and 12 h subgroups of ischaemic priapism. The experimental model was created using a vacuum erection device and constrictive tape technique, and intracavernosal MSC were applied immediately after the tape was removed. After 4 weeks, intracavernosal pressures (ICPs) and systemic mean arterial pressure (MAP) were measured. Penectomy was then performed to assess histopathological and molecular changes in the rats’ penile tissues. Results: In the ischaemic priapism model, MSC therapy showed significant improvements in peak and mean ICPs and mean ICP/MAP ratio. Histopathological analysis showed significant increases in smooth-muscle/collagen ratio and e-NOS and n-NOS expression. Although there was a decrease in fibrosis, it was not significant. At the molecular level, there were significant decreases in TGF-beta and VEGF mRNA expression, whilst NGF and BDNF mRNA-expression levels showed significant increases with MSC therapy. In terms of ICPs, the therapy showed more significant improvements in short-term priapism. However, when looking at histopathological and molecular parameters, the therapy had positive effects on a wider range of parameters in the long-term priapism. Conclusion: MSC treatment improved cavernosal physiology and had positive effects at the histopathological and molecular level in the ischaemic priapism model.
dc.identifier.citationKılıç, E., Çolakerol, A., Temiz, M. Z., Yentur, S., Başağa, Y., Tavukçu, H. H. ... Kandıralı, İ. E. (2025). Intracavernosal mesenchymal stem cell therapy in ischaemic priapism: an experimental study. International Urology and Nephrology, 57(3), 723-734. http://dx.doi.org/10.1007/s11255-024-04248-6
dc.identifier.doi10.1007/s11255-024-04248-6
dc.identifier.endpage734
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue3
dc.identifier.pmid39443434
dc.identifier.scopus2-s2.0-85207230233
dc.identifier.scopusqualityQ2
dc.identifier.startpage723
dc.identifier.urihttp://dx.doi.org/10.1007/s11255-024-04248-6
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13094
dc.identifier.volume57
dc.identifier.wosWOS:001340520700005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTavukçu, Hasan Hüseyin
dc.institutionauthorid0000-0003-0956-7460
dc.language.isoen
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMesenchymal Stem Cell
dc.subjectPenile Erection
dc.subjectPriapism
dc.subjectTreatment
dc.titleIntracavernosal mesenchymal stem cell therapy in ischaemic priapism: an experimental study
dc.typeArticle

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