Stevioside improves brain oxidant-antioxidant status in overfed zebrafish

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dc.authorid0000-0003-0804-1475
dc.authorid0000-0002-6274-801X
dc.contributor.authorDandin, Esra
dc.contributor.authorÜnal, İsmail
dc.contributor.authorBeler, Merih
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorCansız, Derya
dc.contributor.authorAteş Kalkan, Perihan Seda
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned2024-01-30T07:03:41Z
dc.date.available2024-01-30T07:03:41Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: An excessive buildup of adipose tissue is a defining feature of overnutrition, and a significant fraction of the world's population suffers from obesity. Overnutrition is associated with the deterioration of mitochondrial functions in the brain in the case of obesity. In this study, we evaluated the effects of stevioside (ST) which is a calorie-free, naturally occurring herbal sweetener made from Stevia rebaudiana (Bertoni) on the oxidant-antioxidant balance in the brain in cases of overnutrition. Accordingly, the effects of ST consumption on the oxidant-antioxidant balance in the brain was evaluated and determined in a case study of overfeeding adult zebrafish for 15 days. Materials and Methods: Zebrafish were placed in four groups; the control group (C); overfed group (OF); low-dose (1mg/L) ST treated OF group (OF+LDS); and the high-dose ST (5mg/L) treated OF group (OF+HDS). The levels of lipid peroxidation (LPO) were evaluated together with nitric oxide (NO) to determine the oxidant status. The antioxidant status from the activities of the superoxide dismutase (SOD) and glutathione S-transferase (GST) were determined in brain tissues. Results: The ST treatment decreased the increased LPO and NO levels in overfed zebrafish and increased SOD and GST activities in a dose-dependent manner. Conclusion: ST exerted an antioxidant effect on the possible damage mechanisms that could occur in the brain in case of overnutrition by decreasing oxidative stress and improving the antioxidant enzyme activities.
dc.description.sponsorshipMarmara University Scientific Research Projects Commissionen_US
dc.identifier.citationDandin, E., Ünal, İ., Beler, M., Üstündağ, Ü. V., Cansız, D., Ateş Kalkan, P. S. ... Emekli Alturfan, E. (2023). Stevioside improves brain oxidant-antioxidant status in overfed zebrafish. European Journal of Biology, 82(2), 258-262. https://dx.doi.org/10.26650/EurJBiol.2023.1301847
dc.identifier.doi10.26650/EurJBiol.2023.1301847
dc.identifier.endpage262
dc.identifier.issn2602-2575
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85182223160
dc.identifier.scopusqualityQ4
dc.identifier.startpage258
dc.identifier.urihttps://dx.doi.org/10.26650/EurJBiol.2023.1301847
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12214
dc.identifier.volume82
dc.indekslendigikaynakScopus
dc.institutionauthorÜstündağ, Ünsal Veli
dc.institutionauthorCansız, Derya
dc.language.isoen
dc.publisherIstanbul University Press
dc.relation.ispartofEuropean Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.en*
dc.subjectBrain
dc.subjectOverfeeding
dc.subjectOxidant-Antioxidant Status
dc.subjectStevioside
dc.subjectZebrafish
dc.titleStevioside improves brain oxidant-antioxidant status in overfed zebrafish
dc.typeArticle

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