Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay

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dc.authorid0000-0002-8440-367X
dc.authorid0000-0002-5767-1791
dc.contributor.authorWeber, Megan L.
dc.contributor.authorHsin, Hong-Yuan
dc.contributor.authorKalay, Ersan
dc.contributor.authorBrozkova, Dana Safka
dc.contributor.authorShimizu, Takehiko
dc.contributor.authorBayram, Merve
dc.contributor.authorDeeley, Kathleen
dc.contributor.authorKuchler, Erika Calvano
dc.contributor.authorForella, Jessalyn
dc.contributor.authorRuff, Timothy
dc.contributor.authorTrombetta, Vanessa M.
dc.contributor.authorSencak, Regina C.
dc.contributor.authorHummel, Michael
dc.contributor.authorBriseno-Ruiz, Jessica
dc.contributor.authorRevu, Shankar
dc.contributor.authorGranjeiro, Jose Mauro
dc.contributor.authorAntunes, Leonardo Dos Santos
dc.contributor.authorAlves Antunes, Livia Azeredo
dc.contributor.authorAbreu, Fernanda
dc.contributor.authorCosta, Marcelo Castro
dc.contributor.authorTannure, Patricia Nivoloni
dc.contributor.authorKoruyucu, Mine
dc.contributor.authorPatır, Aslı
dc.contributor.authorPoletta, Fernando
dc.contributor.authorMereb, Juan C.
dc.contributor.authorCastilla, Eduardo Enrique
dc.contributor.authorOrioli, Leda M.
dc.contributor.authorMarazita, Mary L.
dc.contributor.authorOuyang, Hongjiao
dc.contributor.authorJayaraman, Thottala
dc.contributor.authorSeymen, Figen
dc.contributor.authorVieira, Alexandre Rezende
dc.date.accessioned2020-06-25T11:41:17Z
dc.date.available2020-06-25T11:41:17Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Çocuk Diş Hekimliği Ana Bilim Dalı
dc.description.abstractBackground: Congenital forms of hearing impairment can be caused by mutations in the estrogen related receptor beta (ESRRB) gene. Our initial linkage studies suggested the ESRRB locus is linked to high caries experience in humans. Methods: We tested for association between the ESRRB locus and dental caries in 1,731 subjects, if ESRRB was expressed in whole saliva, if ESRRB was associated with the microhardness of the dental enamel, and if ESRRB was expressed during enamel development of mice. Results: Two families with recessive ESRRB mutations and DFNB35 hearing impairment showed more extensive dental destruction by caries. Expression levels of ESRRB in whole saliva samples showed differences depending on sex and dental caries experience. Conclusions: The common etiology of dental caries and hearing impairment provides a venue to assist in the identification of individuals at risk to either condition and provides options for the development of new caries prevention strategies, if the associated ESRRB genetic variants are correlated with efficacy.
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Healthen_US
dc.identifier.citationWeber, M. L., Hsin, H.-Y., Kalay, E., Brozkova, D. S., Shimizu, T., Bayram, M. ... Vieira, A. R. (2014). Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay. BMC Medical Genetics, 15. https://dx.doi.org/10.1186/1471-2350-15-81
dc.identifier.doi10.1186/1471-2350-15-81
dc.identifier.issn1471-2350
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5303
dc.identifier.urihttps://dx.doi.org/10.1186/1471-2350-15-81
dc.identifier.volume15
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofBMC Medical Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectDental Caries
dc.subjectDeafness
dc.subjectDental Development
dc.subjectEar Development
dc.subjectLinkage Disequilibrium
dc.subjectGenetics
dc.subjectPolymorphisms
dc.titleRole of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay
dc.typeArticle

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