The relationship of arginophilic proteins of the nuclear organized regions and atopic dermatitis in children

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dc.authorid0000-0003-4479-3404
dc.authorid0000-0002-2621-1397
dc.authorid0000-0002-6490-4530
dc.authorid0000-0002-3554-7941
dc.contributor.authorGündüz, Mehmet
dc.contributor.authorOkur, Mesut
dc.contributor.authorAksoy Okan, Meliha
dc.contributor.authorŞengil, Ahmet Zeki
dc.contributor.authorTemel, Hayrettin
dc.contributor.authorCömert, Murat
dc.date.accessioned2020-07-07T12:08:57Z
dc.date.available2020-07-07T12:08:57Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractBackround: The arginophilic proteins of nuclear organized regions (AgNOR), visualized with colloidal silver methods as black dots are known as AgNOR. To date, the relationship between AgNOR and cancer and inflammatory conditions has been investigated. However, there has been no report investigating the relationship between AgNOR and atopic dermatitis. The aim of this study was to investigate the relationship between atopic dermatitis and AgNOR in paediatric patients. Methods: Twenty-nine children with atopic dermatitis and 23 healthy children were included in the study. AgNOR test results were analysed prospectively. Results: The mean AgNOR number (40.19 +/- 21.06) in the patient group was significantly higher than the control group (12.83 +/- 10.40) (P<.001). Conclusions: This study investigated the association between AgNOR and atopic dermatitis for the first time in the literature. In the study, atopic dermatitis and AgNOR were found to be related. In the study, for the first time with the ROC analysis, AgNOR limit values with high sensitivity and specificity levels were determined in the diagnosis of atopic dermatitis.
dc.identifier.citationGündüz, M., Okur, M., Aksoy Okan, M., Şengil, Ahmet Z., Temel, H. ve Cömert, M. (2019). The relationship of arginophilic proteins of the nuclear organized regions and atopic dermatitis in children. Experimental Dermatology, 28(11), 1309-1312. https://dx.doi.org/10.1111/exd.14031
dc.identifier.doi10.1111/exd.14031
dc.identifier.endpage1312
dc.identifier.issn0906-6705
dc.identifier.issn1600-0625
dc.identifier.issue11
dc.identifier.scopusqualityQ1
dc.identifier.startpage1309
dc.identifier.urihttps://dx.doi.org/10.1111/exd.14031
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5411
dc.identifier.volume28
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofExperimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAtopic Dermatitis
dc.subjectAgNOR
dc.subjectNuclear Organized Regions
dc.titleThe relationship of arginophilic proteins of the nuclear organized regions and atopic dermatitis in children
dc.typeArticle

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