A novel theanine complex, Mg-L-Theanine improves sleep quality via regulating brain electrochemical activity

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dc.authorid0000-0003-2251-2093
dc.authorid0000-0001-7266-9844
dc.authorid0000-0003-4514-2902
dc.authorid0000-0002-9476-8488
dc.contributor.authorDaşdelen, Muhammed Furkan
dc.contributor.authorEr, Sezgin
dc.contributor.authorKaplan, Berkan
dc.contributor.authorÇelik, Süleyman
dc.contributor.authorBeker, Mustafa Çağlar
dc.contributor.authorOrhan, Cemal
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorŞahin, Nurhan
dc.contributor.authorMamedova, Havakhanum
dc.contributor.authorSylla, Sarah
dc.contributor.authorKomorowski, James
dc.contributor.authorOjalvo, Sara Perez
dc.date.accessioned2022-05-06T08:23:39Z
dc.date.available2022-05-06T08:23:39Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractL-Theanine is commonly used to improve sleep quality through inhibitory neurotransmitters. On the other hand, Mg2+, a natural NMDA antagonist and GABA agonist, has a critical role in sleep regulation. Using the caffeine-induced brain electrical activity model, here we investigated the potency of L-theanine and two novel Mg-L-theanine compounds with different magnesium concentrations on electrocorticography (ECoG) patterns, GABAergic and serotonergic receptor expressions, dopamine, serotonin, and melatonin levels. Furthermore, we evaluated the sleep latency and duration in the pentobarbital induced sleep model. We herein showed that L-theanine, particularly its various complexes with magnesium increases the expression of GABAergic, serotonergic, and glutamatergic receptors, which were associated with decreased ECoG frequency, increased amplitude, and enhanced delta wave powers. Besides increased dopamine, serotonin, and melatonin; decreased MDA and increased antioxidant enzyme levels were also observed particularly with Mg-complexes. Protein expression analyses also showed that Mg-L-theanine complexes decrease inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) levels significantly. In accordance with these results, Mg complexes improved the sleep latency and duration even after caffeine administration. As a result, our data indicate that Mg-L-theanine compounds potentiate the effect of L-theanine on sleep by boosting slow-brain waves, regulating brain electrical activity, and increasing neurotransmitter and GABA receptor levels.
dc.identifier.citationDaşdelen, M. F., Er, S., Kaplan, B., Çelik, S., Beker, M. Ç., Orhan, C. ... Ojalvo, S. P. (2022). A novel theanine complex, Mg-L-Theanine improves sleep quality via regulating brain electrochemical activity. Frontiers in Nutrition, 9. https://doi.org/110.3389/fnut.2022.874254
dc.identifier.doi10.3389/fnut.2022.874254
dc.identifier.issn2296-861X
dc.identifier.pmid35449538
dc.identifier.scopus2-s2.0-85128691143
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/110.3389/fnut.2022.874254
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9408
dc.identifier.volume9
dc.identifier.wos000790336000001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDaşdelen, Muhammed Furkan
dc.institutionauthorEr, Sezgin
dc.institutionauthorKaplan, Berkan
dc.institutionauthorÇelik, Süleyman
dc.institutionauthorBeker, Mustafa Çağlar
dc.institutionauthorMamedova, Havakhanum
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.relation.ispartofFrontiers in Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectGABA Receptors
dc.subjectL-Theanine
dc.subjectMagnesium
dc.subjectNeurotransmitters
dc.subjectSleep
dc.titleA novel theanine complex, Mg-L-Theanine improves sleep quality via regulating brain electrochemical activity
dc.typeArticle

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