Whipple-ables: clinicopathologic comparison of 1032 cancers removed by pancreatoduodenectomy based on pathologic re-review using refined site-specific criteria

Background: The literature is highly conflicted on the differential clinicopathologic characteristics of cancers arising from differentcompartments of the ampulla-pancreato-biliary tract and duodenum that are removed by pancreatoduodenectomy (Whipple) operation,largely due to differences in the criteria employed (or lack thereof) in the site-specific classification of these cancers until recently. Lack ofstandardized grossing approaches and careful evaluation appear to be significant contributors to the controversy.