Clinicopathological significance of insulin-like growth factor-1 receptor expression in breast cancer

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dc.authorid0000-0003-0128-6947
dc.contributor.authorŞahin, Sevinç
dc.contributor.authorÇakır, Aslı
dc.contributor.authorGönül, İpek Işık
dc.contributor.authorSeçkin, Selda
dc.contributor.authorUluoğlu, Ömer
dc.date.accessioned2021-03-04T07:23:37Z
dc.date.available2021-03-04T07:23:37Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Insulin-like growth factor 1 receptor (IGF1R) is a receptor protein tyrosine kinase that is claimed to be related with tumor development and progression of breast cancer with some conflicting results in the literature. The aims of the study are to investigate expression of IGF1R, and correlate with clinicopathological parameters to clarify the significance of IGF1R on breast cancer.MATERIAL AND METHODS: IGF1R and Ki67 were applied immunohistochemically to the tissue microarray sections of 370 female breast cancer patients. The results were correlated with clinical, prognostic, histopathological features, and other immunohistochemical findings [ER, PR, HER2, CK5/6, and CK14] statistically.RESULTS: IGF1R overexpression showed direct correlation with Ki67 index (P=0.028), HER2 positivity (P=0.001), mitotic count (P=0.004), tumor grade (P=0.015), and geographic necrosis (P=0.023); and negative correlation with ER positivity (P=0.003). There was statistically significant difference between IGF1R expression and the molecular subtypes (P<0.001), mostly HER2+ phenotype. IGF1R expression was found to be higher in invasive ductal carcinoma (IDC) than invasive lobular carcinoma (ILC) (P=0.036). Both IGF1R and Ki67 expression were negatively correlated with disease-free survival (DFS) (P=0.020, P=0.023, respectively) and overall survival (OS) [P<0.001, each] rates. The inverse association between IGF1R overexpression and OS rate was also supported by multivariate analyses (P=0.025).CONCLUSIONS: Overexpression of IGF1R was found to be directly correlated with shorter DFS and OS as well as some clinicopathological features associated with adverse prognosis such as higher Ki67 index, mitotic count, tumor grade, presence of geographic necrosis, HER2 positivity, ER negativity, HER2+ molecular subtype, histological tumor type of IDC rather than ILC. Thus, IGF1R might be considered as an useful target for comprehensive future anti-tumor therapy investigations. Additionally, using IGF1R as well as Ki67 as a part of routine pathology practice might be fruitful in breast cancer therapy and prediction of prognosis.
dc.identifier.citationŞahin, S., Çakır, A., Gönül, İ. I., Seçkin, S. ve Uluoğlu, Ö. (2020). Clinicopathological significance of insulin-like growth factor-1 receptor expression in breast cancer. Annali Italiani di Chirurgia, 91(6), 583-591.
dc.identifier.endpage591
dc.identifier.issn0003-469X
dc.identifier.issn2239-253X
dc.identifier.issue6
dc.identifier.scopusqualityQ3
dc.identifier.startpage583
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6596
dc.identifier.volume91
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEdizioni Luigi Pozzi
dc.relation.ispartofAnnali Italiani di Chirurgiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBreast Carcinoma
dc.subjectIGF1R
dc.subjectInsulin-Like Growth Factor-1 Receptor
dc.subjectImmunohistochemistry
dc.subjectPrognosis
dc.titleClinicopathological significance of insulin-like growth factor-1 receptor expression in breast cancer
dc.typeArticle

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