Transient gonadal activation and infant growth velocity

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dc.authorid0000-0002-1044-6888
dc.contributor.authorKılınç, Suna
dc.contributor.authorHamikçıkan, Şahin
dc.contributor.authorAtay, Enver
dc.contributor.authorAtay, Zeynep
dc.date.accessioned2019-12-27T06:27:01Z
dc.date.available2019-12-27T06:27:01Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Hypothalamic-pituitary-gonadal axis is activated during the first 6 months of life, called as mini-puberty in which reproductive hormone levels may reach to adult levels. Although, our understanding of the pathophysiology of sex steroids interaction with growth in puberty is increasing, very little is known about the relationship between sex steroids and growth at this period of life. Material and Methods: 142 (67 girls, 75 boys) healthy appropriate-for-gestational age neonates were included. Insulin-like growth factor 1(IGF-1), insulin-like growth factor 3 (IGFBP-3), luteinizing hormone (LH), follicle stimulating hormone (FSH), total testosterone (TT) and estradiol (E2) levels were measured at postnatal 2nd month of life. In all cases height and weight were measured at the 1st, 2nd, 4th, 6th, 9th and 12th months of age. GV was monitored and compared with sex steroids and growth factors. Results: The mean LH and TT levels were significantly higher in boys than girls (P = 0.001). In girls, the mean FSH level was significantly higher than in boys (P = 0.001). There was no statistically significant difference between the mean E2, IGF-1 and IGFBP-3 levels in boys and girls (p> 0.05). The GV was significantly faster from birth to 6 months of age in boys than in girls (P <0.05). The highest GV was observed at 1 and 2 months of age, simultaneously with the peak of postnatal gonadal activation. There was a positive correlation between GV and TT in both sexes (P <0.05). Conclusion: These results may provide a new perspective on the effect of transient gonadal activation on infant growth velocity.
dc.identifier.citationKılınç, S., Hamilçıkan, S., Atay, E. ve Atay, Z. (2019). Transient gonadal activation and infant growth velocity. Hormone Research In Paediatrics içinde (231-231. ss.). Karger.
dc.identifier.endpage231
dc.identifier.issn1663-2818
dc.identifier.issn1663-2826
dc.identifier.issueSupplement: 1
dc.identifier.startpage231
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4752
dc.identifier.volume91
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofHormone Research In Paediatricsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMini-Puberty
dc.subjectTestosterone
dc.subjectEstradiol
dc.subjectIGF 1
dc.subjectGrowth Velocity
dc.titleTransient gonadal activation and infant growth velocity
dc.typeConference Object

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