Matrix metalloproteinase-9, neuron-specific enolase, S100 B and tau protein levels in the patients with carbon monoxide poisoning

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dc.authorid0000-0002-7675-0014
dc.contributor.authorCan, Basri
dc.contributor.authorZengin, Suat
dc.contributor.authorEren, Şevki Hakan
dc.contributor.authorBoğan, Mustafa
dc.contributor.authorSabak, Mustafa
dc.contributor.authorGülen, Bedia
dc.contributor.authorUlusal, Hasan
dc.contributor.authorSunar, Mehmet Mustafa
dc.contributor.authorKaraduman, Muhammet Esat
dc.contributor.authorTaysi, Seyithan
dc.date.accessioned2023-08-29T05:57:41Z
dc.date.available2023-08-29T05:57:41Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalı
dc.description.abstractBackground: S100B, NSE, MMP-9, and Tau protein levels increase in cases causing hypoxic cell damage. The diagnosis of the severity of carbon monoxide (CO) poisoning in the early period of these parameters was studied. Material and Methods: COHb level measurement was made using a signal capture CO-pulse oximeter (Masimo's SET Rainbow, Masimo's Co, USA) at the first admission of the patients. Then, COHb levels were confirmed by arterial blood gas(ABG) analysis. The patients were divided into two groups as mild and moderate-severe, according to their Glasgow coma scores (GCS) [Mild (14–15); Moderate (9–13) or Severe (3–8)]. The control group was composed of 16 healthy and non-smoking volunteers. Results: The serum S100B protein and MMP-9 values at 0 hr of admission in the hospital and 3hr of treatment were not significantly different in the patient group as compared to the control group. Tau protein levels were significantly higher in the patient group at 0 and 3 hours (p> 0.05) as compared to healthy person. Conclusion: There was no relationship between CO poisoning and MMP-9 and S100B protein levels. NSE and Tau protein were significantly higher in the patient group than the control group. Tau protein may be more useful marker as compared to neuron-specific enolase.
dc.description.sponsorshipFirat University Scientific Research Projects Management Uniten_US
dc.identifier.citationCan, B., Zengin, S., Eren, Ş. H., Boğan, M., Sabak, M., Gülen, B. ... Taysi, S. (2023). Matrix metalloproteinase-9, neuron-specific enolase, S100 B and tau protein levels in the patients with carbon monoxide poisoning. New Emirates Medical Journal, 4(2). https://dx.doi.org/10.2174/0250688204666230508115135
dc.identifier.doi10.2174/0250688204666230508115135
dc.identifier.issn0250-6882
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85167567172
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://dx.doi.org/10.2174/0250688204666230508115135
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11372
dc.identifier.volume4
dc.indekslendigikaynakScopus
dc.institutionauthorGülen, Bedia
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.ispartofNew Emirates Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCarbon Monoxide Poisoning
dc.subjectMatrix Metalloproteinase 9
dc.subjectHypoxic Cell Damage
dc.subjectTau Protein
dc.subjectAcute Carbon Monoxide
dc.subjectPatients
dc.titleMatrix metalloproteinase-9, neuron-specific enolase, S100 B and tau protein levels in the patients with carbon monoxide poisoning
dc.typeArticle

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