Effects of chromosomal translocations on sperm count in azoospermic and oligospermic cases

Basit Öğe Kaydı
dc.authorid0000-0001-6930-7148
dc.authorid0000-0003-3256-8437
dc.authorid0000-0003-0240-7691
dc.contributor.authorAyaz, Akif
dc.contributor.authorYalçıntepe, Sinem
dc.contributor.authorÖzalp, Özge
dc.contributor.authorYılmaz Güleç, Elif
dc.contributor.authorGezdirici, Alper
dc.contributor.authorAkçay, Ebru Perim
dc.contributor.authorKöseoğlu, Abdullah Hüseyin
dc.date.accessioned2022-11-17T07:59:55Z
dc.date.available2022-11-17T07:59:55Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Geleneksel ve Tamamlayıcı Tıp Araştırma Merkezi
dc.description.abstractPurpose: A number of mechanisms have been proposed for the effect of chromosomal translocations on spermatogenesis and sperm maturation. However, there are still numerous ambiguous issues regarding these two processes. The aim of this study is to evaluate the effect of chromosome break areas on sperm count in the light of the literature. Material and Methods: The study was conducted on the data of 16 male patients with reciprocal or Robertsonian translocation among 152 patients who were admitted to Adana Numune Training and Research Hospital and Kanuni Sultan Suleyman Training and Research Hospital Genetic Diagnosis Centers between 2013 and 2016 due to azoospermia and oligospermia. Results: 11 of these patients had reciprocal and five patients had Robertsonian translocations. All the patients with Robertsonian translocations were detected with azoospermia. Of the patients with reciprocal translocation, five of them were azoospermic and six of them were severe oligospermic. Conclusion: A total of 21 chromosomal breakpoints were identified in the 11 patients with reciprocal translocations. These chromosomal breakpoints may contribute to the clarification of ambiguous issues related to spermatogenesis and sperm maturation. The results also showed the importance of genetic counselling in patients with translocations.
dc.identifier.citationAyaz, A., Yalçıntepe, S., Özalp, Ö., Yılmaz Güleç, E., Gezdirici, A., Akçay, E. P. ... Köseoğlu, A. H. (2022). Effects of chromosomal translocations on sperm count in azoospermic and oligospermic cases. Journal of Basic and Clinical Health Sciences, 6(3), 921-927. https://doi.org/10.30621/jbachs.1069678
dc.identifier.doi10.30621/jbachs.1069678
dc.identifier.endpage927
dc.identifier.issn2458-8938
dc.identifier.issn2564-7288
dc.identifier.issue3
dc.identifier.startpage921
dc.identifier.urihttps://doi.org/10.30621/jbachs.1069678
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9981
dc.identifier.volume6
dc.identifier.wos000877003600027en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAyaz, Akif
dc.institutionauthorAkçay, Ebru Perim
dc.institutionauthorKöseoğlu, Abdullah Hüseyin
dc.language.isoen
dc.publisherDokuz Eylül University Institute of Health Sciences
dc.relation.ispartofJournal of Basic and Clinical Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAzospermia
dc.subjectOligospermia
dc.subjectReciprocal
dc.subjectRobertsonian
dc.titleEffects of chromosomal translocations on sperm count in azoospermic and oligospermic cases
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Ayaz-Akiif-2022.pdf
Boyut:
587.96 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu