Abnormal cortical neural synchronization mechanisms in quiet wakefulness are related to motor deficits, cognitive symptoms, and visual hallucinations in Parkinson's disease patients: an electroencephalographic study

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0003-4292-5717
dc.contributor.authorBabiloni, Claudio
dc.contributor.authorPascarelli, Maria Teresa
dc.contributor.authorLizio, Roberta
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorLopez, Susanna
dc.contributor.authorRizzo, Marco
dc.contributor.authorFerri, Raffaele
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorOrzi, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorSalvetti, Marco
dc.contributor.authorCipollini, Virginia
dc.contributor.authorBonanni, Laura
dc.contributor.authorFranciotti, Raffaella
dc.contributor.authorOnofrj, Marco
dc.contributor.authorStirpe, Paola
dc.contributor.authorFuhr, Peter
dc.contributor.authorGschwandtner, Ute
dc.contributor.authorRansmayr, Gerhard
dc.contributor.authorAarsland, Dag
dc.contributor.authorParnetti, Lucilla
dc.contributor.authorFarotti, Lucia
dc.contributor.authorMarizzoni, Moira
dc.contributor.authorD'Antonio, Fabrizia
dc.contributor.authorDe Lena, Carlo
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYener, Görsev
dc.contributor.authorEmek-Savaş, Derya Durusu
dc.contributor.authorTriggiani, Antonio Ivano
dc.contributor.authorTaylor, John Paul
dc.contributor.authorMcKeith, Ian
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorVacca, Laura
dc.contributor.authorHampel, Harald
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorDe Pandis, Maria Francesca
dc.contributor.authorDel Percio, Claudio
dc.date.accessioned2020-07-27T09:09:11Z
dc.date.available2020-07-27T09:09:11Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractCompared with Alzheimer's disease (AD), Parkinson's disease (PD) shows peculiar clinical manifestations related to vigilance (i.e., executive cognitive deficits and visual hallucinations) that may be reflected in resting-state electroencephalographic rhythms. To test this hypothesis, clinical and resting-state electroencephalographic rhythms in age-, sex-, and education-matched PD patients (N = 136) and Alzheimer's disease patients (AD, N = 85), and healthy older participants (Nold, N = 65), were available from an international archive. Electroencephalographic sources were estimated by eLORETA software. The results are as follows: (1) compared to the Nold participants, the AD and PD patients showed higher widespread delta source activities (PD > AD) and lower posterior alpha source activities (AD > PD); (2) the PD patients with the most pronounced motor deficits exhibited very low alpha source activities in widespread cortical regions; (3) the PD patients with the strongest cognitive deficits showed higher alpha source activities in widespread cortical regions; and (4) compared to the PD patients without visual hallucinations, those with visual hallucinations were characterized by higher posterior alpha sources activities. These results suggest that in PD patients resting in quiet wakefulness, abnormalities in cortical neural synchronization at alpha frequencies are differently related to cognitive, motor, and visual hallucinations. Interestingly, parallel PD neuropathological processes may have opposite effects on cortical neural synchronization mechanisms generating cortical alpha rhythms in quiet wakefulness.
dc.identifier.citationBabiloni, C., Pascarelli, M. T., Lizio, R., Noce, G., Lopez, S., Rizzo, M. ... Del Percio, C. (2020). Abnormal cortical neural synchronization mechanisms in quiet wakefulness are related to motor deficits, cognitive symptoms, and visual hallucinations in Parkinson's disease patients: an electroencephalographic study. Neurobiology of Aging, 91, 88-111. https://dx.doi.org/10.1016/j.neurobiolaging.2020.02.029
dc.identifier.doi10.1016/j.neurobiolaging.2020.02.029
dc.identifier.endpage111
dc.identifier.issn0197-4580
dc.identifier.issn1558-1497
dc.identifier.scopusqualityQ1
dc.identifier.startpage88
dc.identifier.urihttps://dx.doi.org/10.1016/j.neurobiolaging.2020.02.029
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5610
dc.identifier.volume91
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc.
dc.relation.ispartofNeurobiology of Agingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectParkinson's Disease (PD)
dc.subjectResting-State Electroencephalographic (Rseeg) Rhythms
dc.subjectExact Low-Resolution Brain Electromagnetic Source Tomography (Eloreta)
dc.subjectMini-Mental State Evaluation (MMSE)
dc.subjectUnified Parkinson Disease Rating Scale-III (UPDRS III)
dc.subjectVisual Hallucinations
dc.titleAbnormal cortical neural synchronization mechanisms in quiet wakefulness are related to motor deficits, cognitive symptoms, and visual hallucinations in Parkinson's disease patients: an electroencephalographic study
dc.typeArticle

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