The effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injury

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dc.authorid0000-0002-7825-1083
dc.authorid0000-0002-5072-132X
dc.authorid0000-0001-6494-8923
dc.contributor.authorDiker, Nurettin
dc.contributor.authorÇağlayan, Berrak
dc.contributor.authorHelvacıoğlu, Fatma
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned2020-07-13T06:55:20Z
dc.date.available2020-07-13T06:55:20Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractAxonal regeneration of the inferior alveolar nerve (IAN) is a therapeutic target for functional recovery after peripheral nerve injury. Rifampicin exerts anti-apoptotic, anti-inflammatory, and anti-oxidant effects on nerve tissues that may enhance functional recovery after peripheral nerve injury. The aim of the present study was to evaluate the therapeutic effects of systemic rifampicin following IAN crush injury. Following the nerve crush injuries of the IAN, 24 Sprague-Dawley rats were randomly divided into three groups to receive daily intraperitoneal injections of either vehicle, 5 mg kg(-1) rifampicin, or 20 mg kg(-1) rifampicin. Twenty-four days after induction of nerve injuries, Fluorogold (FG) was injected over the mental foramen for the evaluation of neuronal survival. At the end of the four-week period, histologic and histomorphometric examination of IAN samples were performed and FG positive cells were counted in the trigeminal ganglion sections. FG positive cells were significantly more frequent in the 20 and 5 mg kg(-1) rifampicin groups than in the vehicle-treated group. Electron microscopic analyses revealed that the percentage of axons with optimum g-ratio was significantly lower in the vehicle group than in both treatment groups. In conclusion, systemic rifampicin treatment can enhance peripheral nerve regeneration.
dc.description.sponsorshipTurkish Academy of Sciencesen_US
dc.identifier.citationDiker, N., Çağlayan, B., Helvacıoğlu, F. ve Kılıç, E. (2020). The effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injury. European Journal of Oral Sciences, 128(3), 183-189. https://dx.doi.org/10.1111/eos.12691
dc.identifier.doi10.1111/eos.12691
dc.identifier.endpage189
dc.identifier.issn0909-8836
dc.identifier.issn1600-0722
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage183
dc.identifier.urihttps://dx.doi.org/10.1111/eos.12691
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5460
dc.identifier.volume128
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofEuropean Journal of Oral Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMandibular Nerve
dc.subjectNerve Regeneration
dc.subjectRifampicin
dc.subjectTrigeminal Ganglion
dc.titleThe effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injury
dc.typeArticle

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