Urinary tuberculosis: A cohort of 79 adult cases

dc.contributor.authorAltıparmak, Mehmet Rıza
dc.contributor.authorTrabulus, Sinan
dc.contributor.authorBalkan, İlker İnanç
dc.contributor.authorYalın, Serkan Feyyaz
dc.contributor.authorDenizli, Nazım
dc.contributor.authorAslan, Gönül
dc.contributor.authorDoruk, Hasan Erdal
dc.contributor.authorEngin, Aynur
dc.contributor.authorTekin, Recep
dc.contributor.authorBirengel, Serhat
dc.contributor.authorÇetin, Birsen Durmaz
dc.contributor.authorArslan, Ferhat
dc.contributor.authorTurhan, Vedat
dc.contributor.authorMert, Ali
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:50Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:50Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000361339400015
dc.descriptionPubMed ID: 26123266
dc.description.abstractWe aimed to investigate the demographic, clinical, diagnostic, treatment and outcome features of patients with urinary tuberculosis (UTB). Patients with UTB admitted to seven separate centers across Turkey between 1995 and 2013 were retrospectively evaluated. The diagnosis of UTB was made by the presence of any clinical finding plus positivity of one of the following: (1) acid-fast bacilli (AFB) in urine, (2) isolation of Mycobacterium tuberculosis, (3) polymerase chain reaction (PCR) for M. tuberculosis, (4) histopathological evidence for TB. Seventy-nine patients (49.36% male, mean age 50.1 +/- 17.4 years) were included. Mean time between onset of symptoms and clinical diagnosis was 9.7 +/- 8.9 months. The most common signs and symptoms were hematuria (79.7%), sterile pyuria (67.1%), dysuria (51.9%), weakness (51.9%), fever (43%) and costovertebral tenderness (38%). Cystoscopy was performed in 59 (74.6%), bladder biopsy in 18 (22.8%), kidney biopsy in 1 (1.26%) and nephrectomy in 12 (15.2%) patients. Histopathological verification of UTB was achieved in 12 (63.1%) patients who undergone biopsy and in 100% of those undergone nephrectomy. Mycobacterium tuberculosis was isolated in the urine of 50 (63.3%) cases. Four-drug standard anti-TB treatment was the preferred regimen for 87.3% of the patients. Mean treatment duration was 10.5 +/- 2.7 months. Deterioration of renal function occurred in 15 (18.9%) patients two of whom progressed to end-stage renal disease and received hemodialysis. Only one patient died after 74-day medical treatment period. Cases with UTB may present with non-specific clinical features. All diagnostic studies including radiology, cyctoscopy and histopathology are of great importance to exclude UTB and prevent renal failure.
dc.identifier.citationAltıparmak, M. R., Trabulus, S., Balkan, İ. İ., Yalın, S. F., Denizli, N., Aslan, G. ... Mert, A. (2015). Urinary tuberculosis: A cohort of 79 adult cases. Renal Failure, 37(7), 1157-1163. https://dx.doi.org/10.3109/0886022X.2015.1057460
dc.identifier.doi10.3109/0886022X.2015.1057460
dc.identifier.endpage1163
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue7
dc.identifier.scopusqualityQ2
dc.identifier.startpage1157
dc.identifier.urihttps://dx.doi.org/10.3109/0886022X.2015.1057460
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3746
dc.identifier.volume37
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCystoscopy
dc.subjectEpidemiology
dc.subjectRenal Failure
dc.subjectTreatment
dc.subjectUrinary Tuberculosis
dc.titleUrinary tuberculosis: A cohort of 79 adult cases
dc.typeArticle

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