Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation in children: Single-centre experience

Basit Öğe Kaydı
dc.authorid0000-0002-9710-8653
dc.authorid0000-0002-0476-5452
dc.authorid0000-0002-7129-5024
dc.authorid0000-0002-7424-8688
dc.authorid0000-0002-9688-5223
dc.authorid0000-0002-4551-5433
dc.authorid0000-0001-8489-7449
dc.contributor.authorYaman, Yöntem
dc.contributor.authorElli, Murat
dc.contributor.authorŞahin, Şifa
dc.contributor.authorÖzdilli, Kürşat
dc.contributor.authorBilgen, Hülya
dc.contributor.authorBayram, Nihan
dc.contributor.authorNepesov, Serdar
dc.contributor.authorAnak, Sema
dc.date.accessioned2021-10-12T07:39:58Z
dc.date.available2021-10-12T07:39:58Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractDelayed recovery of thrombocytopenia is a well-known complication after allogeneic HSCT. Eltrombopag (ELT), a thrombopoietin receptor agonist (TRAs), induces platelet maturation and release. Mostly conducted in adults, some of the previous studies have shown that ELT seems to enhance platelet recovery for post-allogeneic HSCT thrombocytopenia, appears efficacious, and offers transfusion independence. To evaluate the safety and efficacy of ELT in pediatric patients with prolonged isolated thrombocytopenia (PIT) or secondary failure of platelet recovery (SFPR) after alloHSCT. Retrospective analysis of childhood patients who received treatment with ELT for persistent thrombocytopenia after alloHSCT between May 2016 and August 2019. We evaluated the safety and efficacy of ELT in 18 childhood patients with PIT or SFPR after alloHSCT. Eltrombopag (50 mg/d) treatment was started in all patients, above 6 years of age and 20 kg weight, who had thrombocytopenia despite neutrophil engraftment on the 30th day of HSCT. Our objective was to decrease the need for platelet transfusion and have a platelet count of more than 50 000/mu L. The overall response rate was 77.7%. The median time to achieve a platelet level above 30 000/mu L and 50 000/mu L was 21 and 44 days, respectively. In four patients, platelet count never reached 30 000/mm(3). In two patients, the treatment was discontinued due to grade 3 hepatotoxicity. Our study supports the efficacy and relative safety of ELT use for the treatment of PIT and SFPR seen after alloHSCT in children.
dc.identifier.citationYaman, Y., Elli, M., Şahin, Ş., Özdilli, K., Bilgen, H., Bayram, N. ... Anak, S. (2021). Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation in children: Single-centre experience. Pediatric Transplantation, 25(5). https://dx.doi.org/10.1111/petr.13962
dc.identifier.doi10.1111/petr.13962
dc.identifier.issn1397-3142
dc.identifier.issn1399-3046
dc.identifier.issue5
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1111/petr.13962
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8428
dc.identifier.volume25
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPediatric Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAlloHSCT
dc.subjectEltrombopag
dc.subjectThrombocytopenia
dc.titleEltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation in children: Single-centre experience
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Ozdilli-Kursat-2021.pdf
Boyut:
320.15 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu