Peripheral inflammatory biomarkers as predictors of recurrence in surgically-treated anogenital condylomata acuminata patients

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dc.authorid0000-0002-9452-9276
dc.contributor.authorBasım, ?Pelin
dc.contributor.authorYüksel, Mavişe
dc.date.accessioned2020-12-03T05:31:57Z
dc.date.available2020-12-03T05:31:57Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıklar Ana Bilim Dalı
dc.description.abstractThe aim of this study was to examine the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) in patients with anogenital condylomata acuminata (CA) and their association with recurrence and squamous intraepithelial neoplasia development. We conducted a descriptive study in 95 patients that had undergone surgical treatment for CA. The descriptive data, disease characteristics, and pre-treatment peripheral inflammatory biomarkers (PIBs) were recorded retrospectively. All parameters were compared in those with recurrent and non-recurrent CA. All PIBs were significantly higher in patients with the greatest genital wart size of >2 cm in the squamous intraepithelial lesion (SIL) group. Human papillomavirus (HPV) types 16, 18, 31 and 33, known to carry high risk for anogenital cancer, were significantly related to higher SII. Greater wart size, high-grade squamous intraepithelial lesion (HSIL), and higher PLR and SII values were highly associated with recurrent disease (p = 0.003, 0.006, 0.005 and 0.000, respectively). Of all recurrences, 34.1% were explained by HSIL and increased PLR and SII values. The prediction of CA recurrence is important to determine those patients at high risk. PLR and SII can be used for risk analysis in selected patient groups.
dc.identifier.citationBasım, ?P. ve Yüksel, M. (2020). Peripheral inflammatory biomarkers as predictors of recurrence in surgically-treated anogenital condylomata acuminata patients. International Journal of STD and AIDS, 31(14), 1380-1388. https://dx.doi.org/10.1177/0956462420950562
dc.identifier.doi10.1177/0956462420950562
dc.identifier.endpage1388
dc.identifier.issn0956-4624
dc.identifier.issn1758-1052
dc.identifier.issue14
dc.identifier.scopusqualityQ2
dc.identifier.startpage1380
dc.identifier.urihttps://dx.doi.org/10.1177/0956462420950562
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6069
dc.identifier.volume31
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSAGE Publications Inc
dc.relation.ispartofInternational Journal of STD and AIDSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCondylomata Acuminata
dc.subjectHuman Papilloma Virus
dc.subjectPeripheral Inflammatory Biomarkers
dc.titlePeripheral inflammatory biomarkers as predictors of recurrence in surgically-treated anogenital condylomata acuminata patients
dc.typeArticle

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