Effects of a thermosensitive in situ gel containing mometasone furoate on a rat allergic rhinitis model

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dc.authorid0000-0002-6393-1465
dc.contributor.authorAltuntaş, Ebru
dc.contributor.authorYener, Gülgün
dc.contributor.authorDoğan, Remzi
dc.contributor.authorAksoy, Fadlullah
dc.contributor.authorAydın, Mehmet Şerif
dc.contributor.authorKarataş, Ersin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:39Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:39Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000432900700002
dc.descriptionPubMed ID: 29644886
dc.description.abstractBackground: Mometasone furoate, one of the second generation intranasal corticosteroids, is currently used in suspension form due to its poor solubility. However, this is not favorable for nasal application because of the rapid elimination of the instilled drug from the nasal cavity by mucociliary clearance and delayed onset of action due to the slow dissolution of drug in suspension. Objective: The aim of this study was to determine the antiallergic effects of mucoadhesive thermosensitive in situ gel containing mometasone furoate that we developed previously to prolong the contact between the drug and nasal mucosa and to prevent drainage of the formulation in an ovalbumin-induced rat model of allergic rhinitis. Methods: An experimental allergic rhinitis model was developed in female Wistar albino rats by intraperitoneal injection of ovalbumin every 2 days for 14 days followed by its repeated intranasal instillation for 7 consecutive days. Intranasal instillation of ovalbumin was continued every other day for 14 days. Mometasone furoate in situ gel (5 mu g/10 mu l), mometasone furoate suspension (5 mu g/10 mu l), and physiological saline (10 ml) were administered into the bilateral nasal cavities from day 22 to day 35. Antiallergic effects were evaluated through histopathological evaluation, analysis of ovalbumin-specific serum immunoglobulin E, and a symptom score. Results: Mometasone furoate in situ gel significantly decreased the nasal symptoms and ovalbumin-specific serum immunoglobulin E level as compared with mometasone furoate suspension and physiological saline. Additionally, inflammatory histological symptoms such as mucosal edema, vascular dilatation, eosinophil infiltration, and loss of cilia within the nasal mucosa of allergic rhinitis model rats were remarkably improved with the treatment of mometasone furoate in situ gel. Conclusion: These results suggest that mometasone furoate in situ gel has a better therapeutic potential for the treatment of allergic rhinitis compared to mometasone furoate suspension.
dc.description.sponsorshipScientific Research Project Coordination Unit of Istanbul University [41584]; TUBITAK (The Scientific & Technological Research Council of Turkey) [114S820, 1002]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Scientific Research Project Coordination Unit of Istanbul University (Project Number: 41584) and Rapid Support Program (1002) of TUBITAK (The Scientific & Technological Research Council of Turkey (Project Number: 114S820).en_US
dc.identifier.citationAltuntaş, E., Yener, G., Doğan, R., Aksoy, F., Aydın, M. ve Karataş, E. (2018). Effects of a thermosensitive in situ gel containing mometasone furoate on a rat allergic rhinitis model. American Journal of Rhinology & Allergy, 32(3), 132-138. https://dx.doi.org/10.1177/1945892418764951
dc.identifier.doi10.1177/1945892418764951
dc.identifier.endpage138
dc.identifier.issn1945-8924
dc.identifier.issn1945-8932
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage132
dc.identifier.urihttps://dx.doi.org/10.1177/1945892418764951
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2043
dc.identifier.volume32
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/114S820 1002
dc.relation.ispartofAmerican Journal of Rhinology & Allergyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectThermosensitive
dc.subjectIn Situ Gel
dc.subjectMucoadhesive
dc.subjectAllergic Rhinitis
dc.subjectMometasone Furoate
dc.subjectIntranasal Corticosteroids
dc.subjectSuspension
dc.subjectRat model
dc.subjectOvalbumin
dc.subjectImmunoglobulin
dc.subjectHistopathological Evaluation
dc.titleEffects of a thermosensitive in situ gel containing mometasone furoate on a rat allergic rhinitis model
dc.typeArticle

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