Analyses of changes on skin by aging

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dc.contributor.authorKazancı, Ayşe
dc.contributor.authorKuruş, Meltem
dc.contributor.authorAtasever, Alper
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:04Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:04Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.descriptionWOS: 000393359700007
dc.descriptionPubMed ID: 27321201
dc.description.abstractBackground: This study aimed to evaluate the histological changes occurring in rat skin with increasing age, starting from the intrauterine period. Methods: Thirty-two healthy female Sprague-Dawley rats were evaluated in four groups: group 1 - intrauterine day 19, group 2 - postpartum day 21, group 3 - postpartum day 60, and group 4 - postpartum month 19. Skin samples from the back, abdomen, head, and upper and lower limbs were obtained from each subject under anesthesia. Tissue specimens were evaluated statistically and morphologically for the thicknesses of the epidermis, dermis, and basement membrane; the number, height, and width of dermal papillae; and the mast cell and pilosebaceous counts per group. The changes in collagen/elastic fibers and glycosaminoglycans were also assessed. Results: Epidermal thickness was the highest in the intrauterine group; it decreased in the postpartum period and increased again in the aged group. Basal membrane thickness increased steadily with age. The number, height, and width of dermal papillae and dermal thickness increased up to day 60 after birth although these decreased in the aged group. Mast cell count also reached the maximum in the intrauterine group and gradually decreased with age. Pilosebaceous units of the dermis were fewer in intrauterine specimens; they showed an increase during the postpartum period and a decrease in the aged group. Conclusion: Skin specimens obtained from rats showed striking differences between the intrauterine and postpartum groups. Moreover, the postpartum group showed considerable intra-group differences.
dc.identifier.citationKazancı, A., Kuruş, M. ve Atasever, A. (2017). Analyses of changes on skin by aging. Skin Research and Technology, 23(1), 48-60. https://dx.doi.org/10.1111/srt.12300
dc.identifier.doi10.1111/srt.12300
dc.identifier.endpage60
dc.identifier.issn0909-752X
dc.identifier.issn1600-0846
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage48
dc.identifier.urihttps://dx.doi.org/10.1111/srt.12300
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3798
dc.identifier.volume23
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofSkin Research and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAging
dc.subjectSkin
dc.subjectRat
dc.subjectMorphology
dc.subjectIntrauterine Skin Histology
dc.subjectEpidermal Thickness
dc.subjectMast Cell
dc.titleAnalyses of changes on skin by aging
dc.typeArticle

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