Beneficial effects montelukast, cysteinyl-leukotriene receptor antagonist, on renal damage after unilateral ureteral obstruction in rats

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dc.authorid0000-0001-5254-2563
dc.contributor.authorÖtünçtemur, Alper
dc.contributor.authorÖzbek, Emin
dc.contributor.authorÇakır, Süleyman Sami
dc.contributor.authorDursun, Murat
dc.contributor.authorÇekmen, Mustafa Baki
dc.contributor.authorPolat, Emre Can
dc.contributor.authorÖzcan, Levent
dc.contributor.authorSomay, Adnan
dc.contributor.authorÖzel Özbay, Nurver
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:30Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:30Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.descriptionWOS: 000354634500014
dc.descriptionPubMed ID: 26005969
dc.description.abstractIntroduction: Ureteral obstruction is a common pathology and caused kidney fibrosis and dysfunction at late period. In this present, we investigated the antifibrotic and antiinflammatory effects of montelukast which is cysteinyl leukotriene receptor antagonist, on kidney damage after unilateral ureteral obstruction(UUO) in rats. Materials and Methods: 32 rats divided four groups. Group 1 was control, group 2 was sham, group 3 was rats with UUO and group 4 was rats with UUO which were given montelukast sodium (oral 10 mg/kg/day). After 14 days, rats were killed and their kidneys were taken and blood analysis was performed. Tubular necrosis, mononuclear cell infiltration and interstitial fibrosis scoring were determined histopathologically in a part of kidneys; nitric oxide(NO), malondialdehyde(MDA) and reduced glutathione(GSH) levels were determined in the other part of kidneys. Urea-creatinine levels were investigated at blood analysis. Statistical analyses were made by the Chi-square test and one-way analysis of variance (ANOVA). Results: There was no difference significantly for urea-creatinine levels between groups. Pathologically, there was serious tubular necrosis and fibrosis in group 3 and there was significantly decreasing for tubular necrosis and fibrosis in group 4(p<0.005). Also, there was significantly increasing for NO and MDA levels; decreasing for GSH levels in group 3 compared the other groups(p<0.005). Conclusion: We can say that montelukast prevent kidney damage with antioxidant effect, independently of NO.
dc.identifier.citationÖtünçtemur, A., Özbek, E., Çakır, S. S., Dursun, M., Çekmen, M. B. Polat, E. C. ... Özel Özbay, N. (2015). Beneficial effects montelukast, cysteinyl-leukotriene receptor antagonist, on renal damage after unilateral ureteral obstruction in rats. Brazilian Society of Urology, 41(2), 279-287. https://dx.doi.org/10.1590/S1677 5538.IBJU.2015.02.14
dc.identifier.doi10.1590/S1677-5538.IBJU.2015.02.14
dc.identifier.endpage287
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage279
dc.identifier.urihttps://dx.doi.org/10.1590/S1677-5538.IBJU.2015.02.14
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2725
dc.identifier.volume41
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBrazilian Society of Urology
dc.relation.ispartofInternational Brazilian Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMontelukast [Supplementary Concept]
dc.subjectCysteinyl-Leukotriene [Supplementary Concept]
dc.subjectRenal Insufficiency
dc.subjectUreteral Obstruction
dc.titleBeneficial effects montelukast, cysteinyl-leukotriene receptor antagonist, on renal damage after unilateral ureteral obstruction in rats
dc.typeArticle

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