Lower prepulse inhibition in clinical high-risk groups but not in familial risk groups for psychosis compared with healthy controls

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dc.authorid0000-0001-5118-4776
dc.contributor.authorTogay, Bilge
dc.contributor.authorÇıkrıkçılı, Uğur
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorUslu, Atilla
dc.contributor.authorNoyan, Handan
dc.contributor.authorÜçok, Alp
dc.date.accessioned2019-12-20T09:10:13Z
dc.date.available2019-12-20T09:10:13Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractAim: Although the lower level of prepulse inhibition (PPI) of the startle response is well known in schizophrenia, the onset of this difference is not clear. The aim of the present study was to compare PPI in individuals with clinical and familial high risk for psychosis, and healthy controls. Methods: We studied PPI in individuals within three groups: ultra-high risk for psychosis (UHR, n = 29), familial high risk for psychosis (FHR, n = 24) and healthy controls (HC, n = 28). The FHR group was chosen among siblings of patients with schizophrenia, whereas UHR was defined based on the Comprehensive Assessment of At-Risk Mental States (CAARMS). We collected clinical data using the BPRS-E, SANS and SAPS when individuals with UHR were antipsychotic-naïve. A cognitive battery that assessed attention, cognitive flexibility, working memory, verbal learning and memory domains was applied to all participants. Results: PPI was lower in the UHR group compared with both the FHR and HC groups. Those with a positive family history for schizophrenia had lower PPI than others in the UHR group. There was no difference in PPI between the FHR and HC groups. We found no relationship between PPI and cognitive performance in the three groups. Startle reactivity was not different among the three groups. Positive and negative symptoms were not related to PPI and startle reactivity in the UHR group. Conclusions: Our findings suggest that clinical and familial high-risk groups for psychosis have different patterns of PPI.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul Universitesien_US
dc.identifier.citationTogay, B., Çıkrıkçılı, U., Bayraktaroğlu, Z., Uslu, A., Noyan, H. ve Üçok, A. (2020). Lower prepulse inhibition in clinical high-risk groups but not in familial risk groups for psychosis compared with healthy controls. Early Intervention in Psychiatry, 14(2), 196-202. http://dx.doi.org/10.1111/eip.12845
dc.identifier.doi10.1111/eip.12845
dc.identifier.endpage202
dc.identifier.issn1751-7885
dc.identifier.issn1751-7893
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage196
dc.identifier.urihttp://dx.doi.org/10.1111/eip.12845
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4578
dc.identifier.volume14
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofEarly Intervention in Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectClinical High Risk for Psychosis
dc.subjectCognition
dc.subjectFamilial Risk for Psychosis
dc.subjectPrepulse Inhibition
dc.titleLower prepulse inhibition in clinical high-risk groups but not in familial risk groups for psychosis compared with healthy controls
dc.typeArticle

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