Identification of ApoA1, HPX and POTEE genes by omic analysis in breast cancer

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dc.authorid0000-0002-8814-7351
dc.contributor.authorÇine, Naci
dc.contributor.authorBaykal, Ahmet Tarık
dc.contributor.authorSünnetçi, Deniz
dc.contributor.authorCantürk, Zafer
dc.contributor.authorSerhatlı, Müge
dc.contributor.authorSavlı, Hakan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:13Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:13Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.descriptionWOS: 000339983200027
dc.descriptionPubMed ID: 24969553
dc.description.abstractBreast cancer is the most common cancer among women and accounts for 23% of all female types of cancers. It is well recognized that breast cancer represents a heterogeneous group of tumors, and the molecular events involved in the progression to cancer remain undetermined. Moreover, available prognostic and predictive markers are not sufficient for the accurate determination of the risk for many breast cancer patients. Thus, it is necessary to discover new molecular markers for accurate prediction of clinical outcome and individualized therapy. In the present study, we performed omics-based whole-genome trancriptomic and whole proteomic profiling with network and pathway analyses of breast tumors to identify gene expression patterns related to clinical outcome. A total of 20 samples from tumors and 14 normal appearing breast tissues were analyzed using both gene expression microarrays and LC-MS/MS. We identified 585 downregulated and 413 upregulated genes by gene expression microarrays. Among these genes, HPX, POTEE and ApoAl were the most significant genes correlated with the proteomic profile. Our data revealed that these identified genes are closely related to breast cancer and may be involved in robust detection of disease progression.
dc.description.sponsorshipKocaeli University BAP [2009/022]en_US
dc.description.sponsorshipThis study was generously supported by Kocaeli University BAP (no. 2009/022). Label-free shotgun proteomic analysis and data analysis were designed and performed at the Department of Medical Biochemistry, School of Medicine, Istanbul Medipol University, Istanbul, Turkey and the Genetic Engineering and Biotechnology Institute, Marmara Research Center, TUBITAK, Kocaeli, Turkey. All microarray studies, gene network and gene set enrichments were analyzed at the Department of Medical Genetics, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.en_US
dc.identifier.citationÇine, N., Baykal, A. T., Sünnetçi, D., Cantürk, Z., Serhatlı, M. ve Savlı, H. (2014). Identification of ApoA1, HPX and POTEE genes by omic analysis in breast cancer. Oncology Reports, 32(3), 1078-1086. https://dx.doi.org/10.3892/or.2014.3277
dc.identifier.doi10.3892/or.2014.3277
dc.identifier.endpage1086
dc.identifier.issn1021-335X
dc.identifier.issn1791-2431
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage1078
dc.identifier.urihttps://dx.doi.org/10.3892/or.2014.3277
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3587
dc.identifier.volume32
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpandidos Publications
dc.relation.ispartofOncology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMicroarray
dc.subjectBreast Cancer
dc.subjectOmic Analysis
dc.subjectMMP-9
dc.subjectNF-Kappa B
dc.subjectApoA1
dc.subjectHPX
dc.subjectPOTEE
dc.titleIdentification of ApoA1, HPX and POTEE genes by omic analysis in breast cancer
dc.typeArticle

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