Echocardiographic epicardial fat thickness is related to altered blood pressure responses to exercise stress testing

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dc.contributor.authorŞengül, Cihan
dc.contributor.authorÖzveren, Olcay
dc.contributor.authorDuman, Dursun
dc.contributor.authorEroğlu, Elif
dc.contributor.authorOduncu, Vecih
dc.contributor.authorTanboğa, Halil İbrahim
dc.contributor.authorCan, Mehmet Mustafa
dc.contributor.authorAkgün, Taylan
dc.contributor.authorDindar, İsmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:36Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:36Z
dc.date.issued2011
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractObjective. Hypertensive response at peak exercise and blunted blood pressure (BP) recovery, altered BP responses obtained from exercise stress testing, have been suggested as risk factors for future onset of hypertension in previous studies. Epicardial fat, a new cardiometabolic risk factor, has been linked to hypertension in some recent studies. In this study, we tested the primary hypothesis suggesting that the epicardial fat thickness (EFT) is related to altered BP responses to treadmill exercise testing. We also evaluated the sensitivity and specificity of the EFT as a predictor of hypertensive response to peak exercise. Methods. Normotensive subjects underwent to treadmill stress testing and transthoracic echocardiography. Hypertensive response to peak treadmill exercise testing was defined as ? 210/105 mmHg and ?190/105 mmHg at peak exercise in males and females, respectively. BP recovery index (BPRI) was defined as the ratio of the BP at the 3rd minute of the recovery phase to BP at peak exercise. EFT was measured by echocardiography. Thirty-two subjects with hypertensive response to peak exercise constituted Group 1 and 48 subjects with normal response constituted Group 2. Results. The mean EFT of subjects in Group 1 was significantly higher (8.2 ± 1.1 mm vs 5.1 ± 1.5 mm; p = 0.0001) than subjects in Group 2. In correlation analysis performed in Group 1, EFT was found to be significantly correlated with BPRI (r = 0.51, p < 0.003). An EFT of ?6.5 mm predicted the hypertensive response to peak exercise test with 68.8% sensitivity and 87.5% specificity (receiving operator characteristic area under curve: 0.879, 95% CI 0.7930.965, p < 0.001). Patients with EFT ?6.5 mm showed a significantly increased BPRI (0.89 ± 0.07 vs 0.74 ± 0.09, p < 0.0001) and peak systolic BP (198.4 ± 15.3 mmHg vs 169.4 ± 19.8 mmHg, p < 0.0001). There were significant differences in metabolic equivalents, maximum heart rate, homeostatic model assessment of insulin resistance, high-density lipoprotein-cholesterol, waist circumference and age values between two patients groups dichotomized according to the cut-off value of EFT. BPRI was the only independent variable related to EFT in the multivariate analysis (odds ratio = 1.4, 95% CI 2.757.16, p = 0.001). Conclusions. EFT was found to be related to altered BP responses to exercise stress testing. The echocardiographic measurement of EFT may serve as a useful non-invasive indicator of heightened risk of future hypertension.
dc.identifier.citationŞengül, C., Özveren, O., Duman, D., Eroğlu, E., Oduncu, V., Tanboğa, H. İ. ... Dindar, İ. (2011). Echocardiographic epicardial fat thickness is related to altered blood pressure responses to exercise stress testing. Blood Pressure, 20(5), 303-308. https://dx.doi.org/10.3109/08037051.2011.569992
dc.identifier.doi10.3109/08037051.2011.569992
dc.identifier.endpage308
dc.identifier.issn0803-7051
dc.identifier.issue5
dc.identifier.scopusqualityQ2
dc.identifier.startpage303
dc.identifier.urihttps://hdl.handle.net/20.500.12511/863
dc.identifier.urihttps://dx.doi.org/10.3109/08037051.2011.569992
dc.identifier.volume20
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofBlood Pressureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBlood Pressure Recovery Index
dc.subjectEchocardiography
dc.subjectEpicardial Fat
dc.subjectExercise Stress Test
dc.subjectHypertension
dc.subjectVisceral Adiposity
dc.titleEchocardiographic epicardial fat thickness is related to altered blood pressure responses to exercise stress testing
dc.typeArticle

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