SIRT1 gene variants are related to risk of childhood obesity

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dc.authorid0000-0002-6895-8560
dc.contributor.authorKılıç, Ülkan
dc.contributor.authorGök, Özlem
dc.contributor.authorElibol, Birsen
dc.contributor.authorÖzgen, İlker Tolga
dc.contributor.authorErenberk, Ufuk
dc.contributor.authorUysal, Ömer
dc.contributor.authorDündaröz, Mehmet Ruşen
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:55:55Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:55:55Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.descriptionWOS: 000351515300008
dc.descriptionPubMed ID: 25233986
dc.description.abstractObesity is a multifactorial disorder resulting from the interaction between genetic, psychological, physical, environmental, and socioeconomic factors. SIRT1 gene has important effects on the regulation of adiponectin, caloric restriction, insulin sensitivity, coronary atherosclerosis, and cardiovascular diseases. The aim of this study was to investigate the association between childhood obesity and SIRT1 gene polymorphisms regarding rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5 using PCR-CTPP method in 120 obese and 120 normal weight children. In this study, BMI, systolic and diastolic blood pressure, LDL cholesterol, triglyceride, and insulin levels were significantly higher and HDL-cholesterol levels were significantly lower in obese children compared to normal weight children. For rs7895833 A > G, the rate of having AG genotype and G allele was significantly higher in obese children compared to non-obese group (p < 0.001). The risk for obesity was increased by 1.9 times in G allele carriers; therefore, A allele may be protective against obesity. Both study groups had CT heterozygote genotype for rs2273773 C > T. There was no significant difference for rs7069102 C > G gene polymorphism between groups. Conclusion: This is the first study reporting an association between SIRT1 gene polymorphisms and obesity in children.
dc.description.sponsorshipUniversity Research Council, Bezmialem Vakif University [BAP: 9.2012/15]en_US
dc.description.sponsorshipThis study was supported by grants from the University Research Council, Bezmialem Vakif University (BAP: 9.2012/15). The authors would like to thank Assoc. Prof. Dr. Arzu Ergen for her help in this study.en_US
dc.identifier.citationKılıç, Ü., Gök, Ö., Elibol, B., Özgen, İ. T., Erenberk, U., Uysal, Ö. ve Dündaröz, M. R. (2015). SIRT1 gene variants are related to risk of childhood obesity. European Journal of Pediatrics, 174(4), 473-479. https://dx.doi.org/10.1007/s00431-014-2424-1
dc.identifier.doi10.1007/s00431-014-2424-1
dc.identifier.endpage479
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.startpage473
dc.identifier.urihttps://dx.doi.org/10.1007/s00431-014-2424-1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2471
dc.identifier.volume174
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectSIRT1
dc.subjectChildhood Obesity
dc.subjectEpigenetic
dc.subjectPCR-CTPP
dc.subjectSNP
dc.titleSIRT1 gene variants are related to risk of childhood obesity
dc.typeArticle

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