Investigation of the genotoxic effect and trace element levels of the nickel-titanium arc-wires used in orthodontic treatment

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dc.contributor.authorErdem, Onur
dc.contributor.authorŞimsek Çetinkaya, Şahika
dc.contributor.authorKaplan, M.
dc.contributor.authorÇırak, Eyüp
dc.contributor.authorGökçe, Sıla Mermut
dc.contributor.authorAkay, Cemal
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:19Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:19Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Ortodonti Ana Bilim Dalı
dc.description52nd Congress of the European-Societies-of-Toxicology (EUROTOX) -- SEP 04-07, 2016 -- Seville, SPAIN
dc.descriptionWOS: 000402436700891
dc.description.abstractNickel-titanium alloy arch-wires are the most frequently used biomaterials thanks to their biocompatibility in orthodontic treatment. Despite these properties we have some evidence about carcinogenic, mutagenic and cytotoxic effects of the materials is associated with their corrosion properties. In this study, we aimed to investigate the genotoxic effects using Micronucleus (MN) technique in 32 patients (consisting of 16 boys and 16 girls whose ages range from 12 to 17) undergoing the Ni-Ti arc-wires treatment. Also, some bioelement (Fe, Cu and Zn) levels in saliva were determined for certain sampling times. The sampling time for patients is 0 (as control) 7th, 15th, 30th, 45th, 60th and 90th days. The mean MN frequency per 1000 cells has increased significantly in days 7, 15, 30 and 45 compared to the control group. However, there was not a significant difference between the 60th and the control group. In addition, the mean MN frequency in the 90th day was found to decrease significantly compared to the control group. Cu values in the saliva samples showed a statistically significant increase in all experimental groups compared to the control group, while there was a significant decrease in Fe and Zn values compared to the control group. Consequently, it has been determined that the genotoxic effects related to Ni-Ti alloy wire were at identifiable levels; however, these effects did not pose a problem in terms of the long-term biocompatibility of the materials.
dc.description.sponsorshipEuropean Society of Toxicologyen_US
dc.identifier.citationErdem, O., Çetinkaya, S., Kaplan, M., Çırak, E., Gökçe, S. ve Akay, C. (2016). Investigation of the genotoxic effect and trace element levels of the nickel-titanium arc-wires used in orthodontic treatment. 52nd Congress of the European-Societies-of-Toxicology (EUROTOX) içinde (S297-S297. ss.). Seville: Spain, September 04-07, 2016. https://dx.doi.org/10.1016/j.toxlet.2016.06.2030
dc.identifier.doi10.1016/j.toxlet.2016.06.2030
dc.identifier.endpageS297
dc.identifier.issn0378-4274
dc.identifier.issn1879-3169
dc.identifier.issueSupplement: S
dc.identifier.startpageS297
dc.identifier.urihttps://dx.doi.org/10.1016/j.toxlet.2016.06.2030
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3848
dc.identifier.volume258
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartof52nd Congress of the European-Societies-of-Toxicology (EUROTOX)en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectToxicology
dc.subjectOrthodontics
dc.subjectDentistry
dc.titleInvestigation of the genotoxic effect and trace element levels of the nickel-titanium arc-wires used in orthodontic treatment
dc.typeConference Object

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