Unravelling the impact of COVID-19 on pregnancy: In aspect of placental histopathology and umbilical cord macrophage immunoactivity with neonatal outcomes

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dc.authorid0000-0003-1985-552X
dc.authorid0000-0003-2496-7673
dc.authorid0000-0002-6984-3079
dc.authorid0000-0002-4243-9092
dc.contributor.authorAltuntaş, Şükriye Leyla
dc.contributor.authorGüneş, Arzu
dc.contributor.authorKaplan, Arife Ahsen
dc.contributor.authorAyşit, Neşe
dc.contributor.authorKeskin, İlknur
dc.date.accessioned2024-02-16T08:01:05Z
dc.date.available2024-02-16T08:01:05Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.description.abstractCOVID-19 has turned into a global pandemic since it was first detected in 2019, causing serious public health problems. Our objective was to investigate the impact of COVID-19 on pregnant women and newborns, who belong to the vulnerable segments of society. Our study involved the histopathological examination of placentas and umbilical cords from two groups of pregnant women. Group I consisted of pregnant women who had never tested positive for COVID-19 during their pregnancy (n: 20). Group II consisted of pregnant women who had contracted COVID-19, exhibited moderate and mild symptoms, and recovered from the disease before giving birth (n: 23). Furthermore, we employed immunofluorescence techniques to detect macrophage activity in the umbilical cord. Prenatal assessments were based on maternal complete blood counts and coagulation assays (n:40 in both groups). Newborn conditions were evaluated using birth weight, height, head circumference, and APGAR (n:40 in both groups). Our analyses reveal that COVID-19 causes placental and umbilical cord inflammation and maternal and foetal vascular malperfussion. Our immunofluorescence investigations demonstrate a notable increase in macrophage numbers and the macrophage-to-total cell ratio within the COVID-19 group. In this aspect, this study provides the initial report incorporating macrophage activity results from Warton's jelly in pregnants who have recovered from COVID-19. We have also ascertained that COVID-19 abbreviates gestation periods and concurrently diminishes maternal haemoglobin concentrations. Consequently, COVID-19 with mild and moderate symptoms during pregnancy, causes significant changes to the placenta and umbilical cord, but propitiously does not cause a significant difference in the neonatal outcomes.
dc.description.sponsorshipHealth Science and Technologies Research Institute ; Koşuyolu Medipol Hospital ; SABITA ; Istanbul Medipol Universityen_US
dc.identifier.citationAltuntaş, Ş. L., Güneş, A., Kaplan, A. A., Ayşit, N. ve Keskin, İ. (2024). Unravelling the impact of COVID-19 on pregnancy: In aspect of placental histopathology and umbilical cord macrophage immunoactivity with neonatal outcomes. Journal of Reproductive Immunology, 162. https://dx.doi.org/10.1016/j.jri.2024.104207
dc.identifier.doi10.1016/j.jri.2024.104207
dc.identifier.issn0165-0378
dc.identifier.issn1872-7603
dc.identifier.pmid38301595
dc.identifier.scopus2-s2.0-85184023914
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1016/j.jri.2024.104207
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12284
dc.identifier.volume162
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAltuntaş, Şükriye Leyla
dc.institutionauthorGüneş, Arzu
dc.institutionauthorKaplan, Arife Ahsen
dc.institutionauthorAyşit, Neşe
dc.institutionauthorKeskin, İlknur
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofJournal of Reproductive Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCOVID-19
dc.subjectImmunofluorescence
dc.subjectInflammation
dc.subjectMacrophage
dc.subjectPlacenta
dc.subjectUmbilical Cord
dc.titleUnravelling the impact of COVID-19 on pregnancy: In aspect of placental histopathology and umbilical cord macrophage immunoactivity with neonatal outcomes
dc.typeArticle

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