Cancer stem cells, their microenvironment and anoikis

Basit Öğe Kaydı
dc.authorid0000-0003-2143-5268
dc.contributor.authorAyla, Şule
dc.contributor.authorKarahüseyinoğlu, Serçin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:35:37Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:35:37Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractTumors are composed of a variety of cancer cells, all of which contribute to tumor heterogeneity. Among these populations of cells, cancer stem cells (CSCs) have an important role in the initiation and progression of cancer. CSCs are maintained extrinsically within the tumor microenvironment, which contains both cellular and physical factors. As a barrier to metastases, cells normally undergo apoptosis (cell death process) after they lose contact with their extracellular matrix or neighboring cells. This cell death process has been termed “anoikis.” The tumor cells that acquire malignant potential develop mechanisms to resist anoikis. The tumor microenvironment has been acknowledged to contribute to anoikis resistance of bystander cancer cells via modulation of the matrix stiffness, enhancement of oxidative stress, production of pro-survival soluble factors, trigger of epithelial-mesenchymal transition (EMT), and self-renewal ability, thus leading to metabolic deregulations of cancer cells. In this article, we review the significance of perivascular cells, extracellular matrix, tumor stiffness, and hypoxia in the regulation of CSC plasticity and anoikis resistance. With a better understanding of the CSC interaction with its niche and anoikis resistance, it is possible to identify potential therapeutic targets for the development of more effective treatments against cancer.
dc.identifier.citationAyla, Ş. ve Karahüseyinoğlu, S. (2019). Cancer stem cells, their microenvironment and anoikis. Critical Reviews in Oncogenesis, 24(1), 27-34. https://dx.doi.org/10.1615/CritRevOncog.2018029433
dc.identifier.doi10.1615/CritRevOncog.2018029433
dc.identifier.endpage34
dc.identifier.issn0893-9675
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage27
dc.identifier.urihttps://hdl.handle.net/20.500.12511/871
dc.identifier.urihttps://dx.doi.org/10.1615/CritRevOncog.2018029433
dc.identifier.volume24
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBegell House Inc.
dc.relation.ispartofCritical Reviews in Oncogenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAnoikis
dc.subjectCancer Stem Cell
dc.subjectEpithelial-Mesenchymal Transition
dc.subjectTumor Microenvironment
dc.titleCancer stem cells, their microenvironment and anoikis
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
ayla-sule(2019).pdf
Boyut:
506.54 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu