3-Pyridinylboronic acid normalizes the effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos

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dc.authorid0000-0003-0804-1475
dc.contributor.authorÜstündağ, Fümet Duygu
dc.contributor.authorÜnal, İsmail
dc.contributor.authorCansız, Derya
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorKara Subaşat, Hülya
dc.contributor.authorAlturfan, Ahmet Ata
dc.contributor.authorMega Tiber, Pınar
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned2022-03-14T07:49:58Z
dc.date.available2022-03-14T07:49:58Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstract1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that damages dopaminergic neurons. Zebrafish has been shown to be a suitable model organism to investigate the molecular pathways in the pathogenesis of Parkinson's disease and also for potential therapeutic agent research. Boron has been shown to play an important role in the neural activity of the brain. Boronic acids are used in combinatorial approaches in drug design and discovery. The effect of 3-pyridinylboronic acid which is an important sub-class of heterocyclic boronic acids has not been evaluated in case of MPTP exposure in zebrafish embryos. Accordingly, this study was designed to investigate the effects of 3-pyridinylboronic acid on MPTP exposed zebrafish embryos focusing on the molecular pathways related to neurodegeneration and apoptosis by RT-PCR. Zebrafish embryos were exposed to MPTP (800 mu M); MPTP + Low Dose 3-Pyridinylboronic acid (50 mu M) (MPTP + LB) and MPTP + High Dose 3-Pyridinylboronic acid (100 mu M) (MPTP + HB) in well plates for 72 hours post fertilization. Results of our study showed that MPTP induced a P53 dependent and Bax mediated apoptosis in zebrafish embryos and 3-pyridinylboronic acid restored the locomotor activity and gene expressions related to mitochondrial dysfunction and oxidative stress due to the deleterious effects of MPTP, in a dose-dependent manner.
dc.identifier.citationÜstündağ, F. D., Ünal, İ., Cansız, D., Üstündağ, Ü. V., Kara Subaşat, H., Alturfan, A. A. ... Emekli Alturfan, E. (2022). 3-Pyridinylboronic acid normalizes the effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos. Drug and Chemical Toxicology, 45(2), 947-954. https://doi.org/10.1080/01480545.2020.1795189
dc.identifier.doi10.1080/01480545.2020.1795189
dc.identifier.endpage954
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue2
dc.identifier.pmid32693643
dc.identifier.scopus2-s2.0-85088382264
dc.identifier.scopusqualityQ3
dc.identifier.startpage947
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1795189
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9114
dc.identifier.volume45
dc.identifier.wos000550941000001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÜstündağ, Ünsal Veli
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject1?Methyl?4?Phenyl?1,2,3,6?Tetrahydropyridine
dc.subject3-Pyridinylboronic Acid
dc.subjectApoptosis
dc.subjectNeurodegeneration
dc.subjectZebrafish Embryo
dc.title3-Pyridinylboronic acid normalizes the effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure in zebrafish embryos
dc.typeArticle

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