Relationship between the change in tumour-infiltrating lymphocyte level and residual tumour after neoadjuvant chemotherapy in patients with locally advanced breast cancer

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dc.authorid0000-0002-3793-5251
dc.authorid0000-0002-0077-6971
dc.authorid0000-0002-0443-6966
dc.authorid0000-0003-0128-6947
dc.authorid0000-0003-2715-4002
dc.authorid0000-0001-7934-7039
dc.authorid0000-0002-9452-9276
dc.contributor.authorErol, Vedat Buğra
dc.contributor.authorGöktaş Aydın, Sabin
dc.contributor.authorBilici, Ahmet
dc.contributor.authorÇakır, Aslı
dc.contributor.authorAçıkgöz, Özgür
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorBasım, Pelin
dc.date.accessioned2024-02-22T07:52:01Z
dc.date.available2024-02-22T07:52:01Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractTo evaluate the tumour-infiltrating lymphocyte (TIL) rates in breast tissue before and after neoadjuvant chemotherapy (NAC) and their impact on survival, eighty-four patients with locally advanced breast cancer (LABC) were assessed. Pre- and post-NAC TIL levels were determined using biopsy and surgical specimens, respectively. The median TIL rate was significantly different before (17.5%) and after (5%) NAC. Pre- and postoperative Ki-67 index, molecular subtype, pre- and post-NAC TIL concentration, and preoperative residual-cancer-burden TIL were significantly associated with pathological complete response (pCR). Specifically, higher pre-NAC TIL levels were associated with higher pCR rates. Postoperative Ki-67 index and pCR, and postoperative Ki-67 index were significant predictors of disease-free (DFS) and overall survival, respectively. The independent prognostic factors for DFS were postoperative Ki-67 score (hazard ratio [HR]: 6.16; p = 0.012), post-NAC TIL score (HR: 0.42; P = 0.041), and pCR (HR: 0.10; P = 0.038). Our study confirms that higher pre-NAC and lower postoperative TIL levels may be surrogate factors for longer DFS, and postoperative TIL rate may predict post-NAC pCR in patients with LABC.
dc.identifier.citationErol, V. B., Göktaş Aydın, S., Bilici, A., Çakır, A., Açıkgöz, Ö., Ölmez, Ö. F. ... Basım, P. (2023). Relationship between the change in tumour-infiltrating lymphocyte level and residual tumour after neoadjuvant chemotherapy in patients with locally advanced breast cancer. Journal of Chemotherapy, 35(7), 662-670. https://dx.doi.org/10.1080/1120009X.2023.2247207
dc.identifier.doi10.1080/1120009X.2023.2247207
dc.identifier.endpage670
dc.identifier.issn1120-009X
dc.identifier.issn1973-9478
dc.identifier.issue7
dc.identifier.pmid37599454
dc.identifier.scopus2-s2.0-85168464195
dc.identifier.scopusqualityQ3
dc.identifier.startpage662
dc.identifier.urihttps://dx.doi.org/10.1080/1120009X.2023.2247207
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12301
dc.identifier.volume35
dc.identifier.wos001051927300001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErol, Vedat Buğra
dc.institutionauthorGöktaş Aydın, Sabin
dc.institutionauthorBilici, Ahmet
dc.institutionauthorÇakır, Aslı
dc.institutionauthorAçıkgöz, Özgür
dc.institutionauthorÖlmez, Ömer Fatih
dc.institutionauthorBasım, Pelin
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofJournal of Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBreast Cancer
dc.subjectBreast Surgery
dc.subjectDisease-Free Survival
dc.subjectNeoadjuvant Chemotherapy
dc.subjectPathological Response
dc.subjectTumour-Infiltrating Lymphocyte
dc.titleRelationship between the change in tumour-infiltrating lymphocyte level and residual tumour after neoadjuvant chemotherapy in patients with locally advanced breast cancer
dc.typeArticle

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