Positioning Europe for the epitranscriptomics challenge

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dc.contributor.authorJantsch, Michael F.
dc.contributor.authorQuattrone, Alessandro
dc.contributor.authorO'Connell, Mary
dc.contributor.authorHelm, Mark
dc.contributor.authorFrye, Michaela
dc.contributor.authorMacias-Gonzales, Manuel
dc.contributor.authorOhman, Marie
dc.contributor.authorAmeres, Stefan
dc.contributor.authorWillems, Luc
dc.contributor.authorFuks, Francois
dc.contributor.authorOulas, Anastasis
dc.contributor.authorVanacova, Stepanka
dc.contributor.authorNielsen, Henrik
dc.contributor.authorBousquet-Antonelli, Cecile
dc.contributor.authorMotorin, Yuri
dc.contributor.authorRoignant, Jean-Yves
dc.contributor.authorBalatsos, Nikolaos
dc.contributor.authorDinnyes, Andras
dc.contributor.authorBaranov, Pavel
dc.contributor.authorKelly, Vincent
dc.contributor.authorLamm, Ayelet
dc.contributor.authorRechavi, Gideon
dc.contributor.authorPelizzola, Mattia
dc.contributor.authorLiepins, Janis
dc.contributor.authorKholodnyuk, Irina Holodnuka
dc.contributor.authorZammit, Vanessa
dc.contributor.authorAyers, Duncan
dc.contributor.authorDrablos, Finn
dc.contributor.authorDahl, John Arne
dc.contributor.authorBujnicki, Janusz
dc.contributor.authorJeronimo, Carmen
dc.contributor.authorAlmeida, Raquel
dc.contributor.authorNeagu, Monica
dc.contributor.authorCostache, Marieta
dc.contributor.authorBankovic, Jasna
dc.contributor.authorBanovic, Bojana
dc.contributor.authorKyselovic, Jan
dc.contributor.authorValor, Luis Miguel
dc.contributor.authorSelbert, Stefan
dc.contributor.authorPir, Pinar
dc.contributor.authorDemircan, Turan
dc.contributor.authorCowling, Victoria
dc.contributor.authorSchaefer, Matthias
dc.contributor.authorRossmanith, Walter
dc.contributor.authorLafontaine, Denis
dc.contributor.authorDavid, Alexandre
dc.contributor.authorCarre, Clement
dc.contributor.authorLyko, Frank
dc.contributor.authorSchaffrath, Raffael
dc.contributor.authorSchwartz, Schraga
dc.contributor.authorVerdel, Andre
dc.contributor.authorKlungland, Arne
dc.contributor.authorPurta, Elzbieta
dc.contributor.authorTimotijevic, Gordana
dc.contributor.authorCardona, Fernando
dc.contributor.authorDavalos, Alberto
dc.contributor.authorBallana, Ester
dc.contributor.authorO'Carroll, Donal
dc.contributor.authorUle, Jernej
dc.contributor.authorFray, Rupert
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:55Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:55Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.descriptionWOS: 000444092300018
dc.descriptionPubMed ID: 29671387
dc.description.abstractThe genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the similar to 150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.
dc.description.sponsorshipCOST Action [CA16120]en_US
dc.description.sponsorshipThis work was suppoerted by the COST Action, (CA16120).en_US
dc.identifier.citationJantsch, M. F., Quattrone, A., O'Connell, M., Helm, M., Helm, M., Macias-Gonzales, M. ... Fray, R. (2018). Positioning Europe for the epitranscriptomics challenge. RNA Biology, 15(6), 829–831. https://dx.doi.org/10.1080/15476286.2018.1460996
dc.identifier.doi10.1080/15476286.2018.1460996
dc.identifier.endpage831
dc.identifier.issn1547-6286
dc.identifier.issn1555-8584
dc.identifier.issue6
dc.identifier.scopusqualityQ1
dc.identifier.startpage829
dc.identifier.urihttps://dx.doi.org/10.1080/15476286.2018.1460996
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3766
dc.identifier.volume15
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Inc.
dc.relation.ispartofRNA Biologyen_US
dc.relation.publicationcategoryDiÄŸer
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDatabase of Modification
dc.subjectDetection of RNA Modification
dc.subjectEpitranscriptomics
dc.subjectEuropean Funding
dc.subjectModel Systems
dc.titlePositioning Europe for the epitranscriptomics challenge
dc.typeEditorial

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