CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL)

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dc.contributor.authorKürtüncü, Murat
dc.contributor.authorKaya, Dilaver
dc.contributor.authorZuliani, Luigi
dc.contributor.authorErdağ, Ece
dc.contributor.authorİçöz, Sema
dc.contributor.authorUğurel, Elif
dc.contributor.authorÇavuş, Filiz
dc.contributor.authorAyşit, Neşe
dc.contributor.authorBirışık, Ömer
dc.contributor.authorVincent, Angela
dc.contributor.authorEraksoy, Mefkure
dc.contributor.authorVural, Burçak
dc.contributor.authorAkman Demir, Gülşen
dc.contributor.authorTüzün, Erdem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:06Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:06Z
dc.date.issued2013
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000312550000006
dc.descriptionPubMed ID: 23111027
dc.description.abstractBackground: Patients with the syndrome of headache with neurological deficits and lymphocytosis (HaNDL) typically present with recurrent and temporary attacks of neurological symptoms and cerebrospinal fluid lymphocytosis. Aim and methods: To identify potential HaNDL-associated antibodies directed against neuronal surface and/or synapse antigens, sera of four HaNDL patients and controls were screened with indirect immunohistochemistry, immunofluorescence, cell-based assay, radioimmunoassay, protein macroarray and enzyme-linked immunosorbent assay (ELISA). Results: Although HaNDL sera did not yield antibodies to any of the well-characterized neuronal surface or synapse antigens, protein macroarray and ELISA studies showed high-titer antibodies to a subunit of the T-type voltage-gated calcium channel (VGCC), CACNA1H, in sera of two HaNDL patients. Conclusion: Our results support the notion that ion channel autoimmunity might at least partially contribute to HaNDL pathogenesis and occurrence of neurological symptoms.
dc.identifier.citationKürtüncü, M., Kaya, D., Zuliani, L., Erdağ, E., İçöz, S., Uğurel, E. ... Tüzün, E. (2013). CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL). Cephalalgia, 33(2), 123-129. https://dx.doi.org/10.1177/0333102412463494
dc.identifier.doi10.1177/0333102412463494
dc.identifier.endpage129
dc.identifier.issn0333-1024
dc.identifier.issue2
dc.identifier.scopusqualityQ1
dc.identifier.startpage123
dc.identifier.urihttps://dx.doi.org/10.1177/0333102412463494
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2147
dc.identifier.volume33
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofCephalalgiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHaNDL
dc.subjectHeadache
dc.subjectCACNA1H
dc.subjectVoltage-Gated Calcium Channel
dc.subjectAutoantibody
dc.titleCACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL)
dc.typeArticle

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