Confocal laser endomicroscopy and optical coherence tomography for the diagnosis of prostate cancer: A needle-based, in vivo feasibility study protocol (Ideal phase 2a)

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dc.authorid0000-0002-6308-1763
dc.contributor.authorSwaan, Abel
dc.contributor.authorMannaerts, Christophe K.
dc.contributor.authorScheltema, Matthijs J. V.
dc.contributor.authorNieuwenhuijzen, Jakko A.
dc.contributor.authorSavcı-Heijink, C. Dilara
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorVan Moorselaar, R. Jeroen A.
dc.contributor.authorVan Leeuwen, Ton G.
dc.contributor.authorDe Reijke, Theo M.
dc.contributor.authorDe Bruin, Daniel Martijn
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:38Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:38Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.descriptionWOS: 000433883200033
dc.descriptionPubMed ID: 29784633
dc.description.abstractBackground: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information. Objective: This study has 2 separate primary objectives. The first is to assess the technical feasibility and safety of in vivo focal imaging with confocal laser endomicroscopy and optical coherence tomography. The second is to identify and define characteristics of prostate cancer and normal prostate tissue in confocal laser endomicroscopy and optical coherence tomography imaging by comparing these images with the corresponding histopathology. Methods: In this prospective, in vivo feasibility study, needle-based confocal laser endomicroscopy and optical coherence tomography imaging will be performed before transperineal template mapping biopsy or radical prostatectomy. First, confocal laser endomicroscopy and optical coherence tomography will be performed in 4 patients (2 for each imaging modality) undergoing transperineal template mapping biopsy to assess the feasibility and safety of confocal laser endomicroscopy and optical coherence tomography. If proven to be safe and feasible, confocal laser endomicroscopy and optical coherence tomography will be performed in 10 patients (5 for each imaging modality) undergoing radical prostatectomy. Confocal laser endomicroscopy and optical coherence tomography images will be analyzed by independent, blinded observers. Confocal laser endomicroscopy-and optical coherence tomography-based qualitative and quantitative characteristics and histopathology will be compared. The study complies with the IDEAL (Idea, Development, Exploration, Assessment, Long-term study) stage2a recommendations. Results: At present, the study is enrolling patients and results and outcomes are expected in 2019. Conclusions: Confocal laser endomicroscopy and optical coherence tomography are promising optical imaging techniques that can visualize and analyze tissue structure, possible tumor grade, and architecture in real time. They can potentially provide real-time, high-resolution microscopic imaging and tissue characteristics of prostate cancer in conjunction with magnetic resonance imaging or transrectal ultrasound fusion-guided biopsy procedures. This study will provide insight into the feasibility and tissue-specific characteristics of confocal laser endomicroscopy and optical coherence tomography for real-time optical analysis of prostate cancer.
dc.description.sponsorshipSTWen_US
dc.description.sponsorshipFunding for this trial was obtained within STW. The funding source had no role in the design of this study and will not have any role during its execution, analyses, interpretation of the data, or decision to submit results.en_US
dc.identifier.citationSwaan, A., Mannaerts, C., Scheltema, M., Nieuwenhuijzen, J., Savcı-Heijink, C., Delarosette, J. ... De Bruin, D. (2018). Confocal laser endomicroscopy and optical coherence tomography for the diagnosis of prostate cancer: A needle-based, ın vivo feasibility study protocol (Ideal phase 2a). JMIR Research Protocols, 7(5). https://dx.doi.org/10.2196/resprot.9813
dc.identifier.doi10.2196/resprot.9813
dc.identifier.issn1929-0748
dc.identifier.issue5
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://dx.doi.org/10.2196/resprot.9813
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2038
dc.identifier.volume7
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJMIR Publications, Inc
dc.relation.ispartofJMIR Research Protocolsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectConfocal Laser Endomicroscopy
dc.subjectOptical Coherence Tomography
dc.subjectProstate
dc.subjectProstatic Neoplasms Biopsy
dc.subjectProstatectomy
dc.subjectMicroscopy
dc.subjectHistology
dc.subjectOptical Imaging
dc.titleConfocal laser endomicroscopy and optical coherence tomography for the diagnosis of prostate cancer: A needle-based, in vivo feasibility study protocol (Ideal phase 2a)
dc.typeArticle

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