The levels of nitrite, nitrate and lipid peroxidation in diabetic mouse brain: The effect of melatonin and pentoxifylline

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dc.authorid0000-0002-8084-7855
dc.authorid0000-0003-0352-1947
dc.contributor.authorYalçınkaya, Ahmet S.
dc.contributor.authorŞekeroğlu, Mehmet Ramazan
dc.contributor.authorHuyut, Zübeyir
dc.contributor.authorÇokluk, Erdem
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorÖztürk, Gürkan
dc.contributor.authorBalahoroğlu, Ragıp
dc.date.accessioned2023-01-17T10:10:44Z
dc.date.available2023-01-17T10:10:44Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractObjective: This study investigated the relationship between diabetes (DM) and nitrite, nitrate and MDA levels and effect of melatonin and pentoxifylline. Methods: Sixty mice were randomly divided into four groups. Control: no action; Diabetes group (DM): after fasting-blood-glucose (FBG) was measured, 150 mg/kg alloxane was applied intraperitoneally three-times every other day; Diabetes + Melatonin (DM + MLT) and Diabetes + Pentoxifylline groups (DM + PTX): following the same procedures with DM, 10 mg/kg melatonin and 50 mg/kg pentoxifylline were administered subcutaneously six days, respectively. Following FBG analysis, brain tissues were taken under the anaesthesia. Nitrite, nitrate and MDA levels were measured. Results: In the all groups with alloxane, FBG were higher than in before application (p <.05). Also, FBG, nitrite, nitrate and MDA levels in the DM + MLT and DM + PTX groups were lower than in the DM (p <.05). Conclusions: Nitrite and nitrate may be related to etiopathogenesis of DM, and pentoxifylline and especially melatonin relatively decrease nitrite, nitrate and lipid peroxidation.
dc.description.sponsorshipYuzuncu Yil Universityen_US
dc.identifier.citationYalçınkaya, A. S., Şekeroğlu, M. R., Huyut, Z., Çokluk, E., Özbek, H., Öztürk, G. ... Balahoroğlu, R. (2022). The levels of nitrite, nitrate and lipid peroxidation in diabetic mouse brain: The effect of melatonin and pentoxifylline. Archives of Physiology and Biochemistry, 128(3), 795-801. https://dx.doi.org/10.1080/13813455.2020.1727528
dc.identifier.doi10.1080/13813455.2020.1727528
dc.identifier.endpage801
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.issue3
dc.identifier.pmid32070146
dc.identifier.scopus2-s2.0-85079770146
dc.identifier.scopusqualityQ3
dc.identifier.startpage795
dc.identifier.urihttps://dx.doi.org/10.1080/13813455.2020.1727528
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10318
dc.identifier.volume128
dc.identifier.wos000514881400001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzbek, Hanefi
dc.institutionauthorÖztürk, Gürkan
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofArchives of Physiology and Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAlloxan
dc.subjectDiabetes Mellitus
dc.subjectMelatonin
dc.subjectOxidative Stress
dc.subjectPentoxifylline
dc.titleThe levels of nitrite, nitrate and lipid peroxidation in diabetic mouse brain: The effect of melatonin and pentoxifylline
dc.typeArticle

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