The neuroprotective effect of coumaric acid on spinal cord ischemia/reperfusion injury in rats

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dc.contributor.authorGüven, Mustafa
dc.contributor.authorŞehitoğlu, Müşerref Hilal
dc.contributor.authorYüksel, Yasemin
dc.contributor.authorTokmak, Mehmet
dc.contributor.authorBozkurt Aras, Adem
dc.contributor.authorAkman, Tarık Muhammed
dc.contributor.authorGölge, Umut Hatay
dc.contributor.authorKaravelioğlu, Ergün
dc.contributor.authorBal, Ercan
dc.contributor.authorÇoşar, Murat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:26Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:26Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.descriptionWOS: 000360847200028
dc.descriptionPubMed ID: 25943038
dc.description.abstractThe main causes of spinal cord ischemia are a variety of vascular pathologies causing acute arterial occlusions. We investigated neuroprotective effects of coumaric acid on spinal cord ischemia injury in rats. Rats were divided randomly into four groups of eight animals as follows: control, ischemia, ischemia + coumaric acid, and ischemia + methylprednisolone. In the control group, only a laparotomy was performed. In all other groups, the spinal cord ischemia was performed by the infrarenal aorta cross-clamping model. Levels of malondialdehyde and nuclear respiratory factor 1 were analyzed, as were the activity of superoxide dismutase. Histopathological and immunohistochemical evaluations were performed. Neurological evaluation was performed with the Tarlov scoring system. The ischemia + coumaric acid group was compared with the ischemia group, and a significant decrease in malondialdehyde and levels was observed. Nuclear respiratory factor 1 level and superoxide dismutase activity of the ischemia + coumaric acid group were significantly higher than in the ischemia group. In histopathological samples, the ischemia + coumaric acid group is compared with the ischemia group, and there was a significant increase in numbers of normal neurons. In immunohistochemical staining, hypoxia-inducible factor-1 alpha and NF-kappa B immunopositive neurons were significantly decreased in the ischemia + coumaric acid group compared with that in the ischemia group. The neurological deficit scores of the ischemia + coumaric acid group were significantly higher than the ischemia group at 24 h. Our results revealed for the first time that coumaric acid exhibits meaningful neuroprotective activity following ischemia-reperfusion injury of the spinal cord.
dc.identifier.citationGüven, M., Şehitoğlu, M. H., Yüksel, Y., Tokmak, M., Bozkurt Aras, A., Akman, T. M. ... Çoşar, M. (2015). The neuroprotective effect of coumaric acid on spinal cord ischemia/reperfusion injury in rats. Inflammation, 38(5), 1986-1995. https://dx.doi.org/10.1007/s10753-015-0179-0
dc.identifier.doi10.1007/s10753-015-0179-0
dc.identifier.endpage1995
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue5
dc.identifier.scopusqualityQ2
dc.identifier.startpage1986
dc.identifier.urihttps://dx.doi.org/10.1007/s10753-015-0179-0
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2702
dc.identifier.volume38
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer New York
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCoumaric Acids
dc.subjectSpinal Cord Ischemia
dc.subjectHypoxia-Inducible Factor 1
dc.subjectNF-Kappa B
dc.titleThe neuroprotective effect of coumaric acid on spinal cord ischemia/reperfusion injury in rats
dc.typeArticle

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