Kaempferol treatment ameliorates memory impairments in STZ-induced neurodegeneration by acting on reelin signaling

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dc.authorid0000-0002-8215-3638
dc.contributor.authorUysal, Melike
dc.contributor.authorÇelikten, Mert
dc.contributor.authorBeker, Merve
dc.contributor.authorPolat, Nurhayat
dc.contributor.authorHüseyinbaş, Önder
dc.contributor.authorTerzioğlu Uşak, Şule
dc.contributor.authorElibol, Birsen
dc.date.accessioned2023-11-07T06:13:55Z
dc.date.available2023-11-07T06:13:55Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.description.abstractMany treatment initiatives, like herbal products and their active ingredients, aim to alleviate neurodegeneration to increase cognitive functions. Kaempferol may be a candidate molecule for treating neurodegeneration because of its antioxidant effects. In the present study, we examined the molecular changes associated with kaempferol’s memory-enhancing effects on streptozotocin (STZ)-induced neurodegeneration. After intracerebroventricular STZ injection in Long-Evans male rats, intraperitoneal kaempferol was administered for 12 days. The Morris water maze (MWM) was used to measure learning and memory performance in the rats, and proteins related to memory formation were investigated in the hippocampi with western blotting. Kaempferol improved learning performance and memory decline in STZ-treated rats. At the molecular level, STZ-induced neurodegeneration resulted in a decrease in the expression of GAD67, reelin, and phosphorylated-NMDAR. However, kaempferol treatment ameliorated these changes by enhancing their levels similar to the controls. While neither STZ injection nor kaempferol treatment produced any significant change in phosphorylated-CAMKII levels, they increased the expression of klotho and prealbumin. These results show that kaempferol has positive effects on memory loss, affecting synaptic plasticity by ameliorating both the levels and activity of memory-relevant molecules through reelin signaling. In summary, this study provides a guide to future studies by examining in detail the healing effect of kaempferol as a candidate molecule in the treatment of neurodegeneration, such as that observed in Alzheimer’s disease.
dc.identifier.citationUysal, M., Çelikten, M., Beker, M., Polat, N., Hüseyinbaş, Ö., Terzioğlu Uşak, Ş. ve Elibol, B. (2023). Kaempferol treatment ameliorates memory impairments in STZ-induced neurodegeneration by acting on reelin signaling. Acta Neurobiologiae Experimentalis, 83(3), 236-245. https://dx.doi.org/10.55782/ane-2023-2427
dc.identifier.doi10.55782/ane-2023-2427
dc.identifier.endpage245
dc.identifier.issn0065-1400
dc.identifier.issn1689-0035
dc.identifier.issue3
dc.identifier.pmid37874194
dc.identifier.scopus2-s2.0-85175089960
dc.identifier.scopusqualityQ3
dc.identifier.startpage236
dc.identifier.urihttps://dx.doi.org/10.55782/ane-2023-2427
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11712
dc.identifier.volume83
dc.identifier.wos001159286500002en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelikten, Mert
dc.language.isoen
dc.publisherNencki Institute of Experimental Biology
dc.relation.ispartofActa Neurobiologiae Experimentalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlzheimer’s Disease
dc.subjectFlavonoid
dc.subjectMemory
dc.subjectNeurodegeneration
dc.subjectSynaptic Plasticit
dc.titleKaempferol treatment ameliorates memory impairments in STZ-induced neurodegeneration by acting on reelin signaling
dc.typeArticle

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