Evaluation of the effect of obesity, dietary glycemic index and metabolic profiles on the cardiovascular risk in children with classical phenylketonuria

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dc.authorid0000-0002-2100-3628
dc.contributor.authorKadıoğlu Yılmaz, Banu
dc.contributor.authorBaykan, Ali
dc.contributor.authorKardaş, Fatih
dc.contributor.authorKendirci, Mustafa
dc.date.accessioned2023-08-21T12:15:38Z
dc.date.available2023-08-21T12:15:38Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjectives: To compare the glycemic index(GI),obesity,echocardiographic,and arterial stiffness measurements with the healthy control group to evaluate the cardiovascular risk of pediatric classical phenylketonuria(PKU). Methods: The study was a prospective observational,involving 104 pediatric volunteers between 2019 and 2020.Two groups were formed:the PKU patient group and the healthy control group.These two groups were further divided into three subgroups:obese,overweight,and normal weight.The patients' anthropometric measurements,body fat analysis,biochemical analysis, GI and glycemic load(GL),arterial stiffness measurements,and echocardiographic findings were recorded. Results: The PKU patient group's glucose,total cholesterol,LDL,and HDL values were significantly lower than the healthy control group(p = 0.010 for glucose and p = 0.001 for total cholesterol,LDL and HDL).Triglyceride levels were higher in the PKU patient group than in the healthy controls(109.6 vs. 76.7 mg/dl,p = 0.001). GI and GL were significantly lower in the PKU patient group than in the healthy control group(GI 453 vs. 392.9,p = 0.017 and GL 101.1 vs. 85.5,p = 0.036).Left ventricular mass(LVM)-z-score and LVM index were significantly higher in the PKU group than in the healthy control group(LVM z-score 0.9 vs. 0.5,p = 0.014 and LVM index 38.9 vs. 32.7 g/m2.7,p = 0.001). A moderately statistically significant positive correlation was found between the mean phenylalanine(phe) value and pulse wave velocity(PWV) among the PKU patient groups(R: 0.477,p < 0.001).A moderately statistically significant positive correlation was also found between waist circumference and PWV in the PKU patient group(R:0.541, p < 0.001). Conclusions: Our study found that close follow-up of phe levels and PWV is more critical than obesity, GI, and GL in the cardiovascular evaluation of classical PKU patients.A large number of multicenter pediatric studies are needed in this area.
dc.identifier.citationKadıoğlu Yılmaz, B., Baykan, A., Kardaş, F. ve Kendirci, M. (2023). Evaluation of the effect of obesity, dietary glycemic index and metabolic profiles on the cardiovascular risk in children with classical phenylketonuria. Molecular Genetics and Metabolism, 140(3). https://dx.doi.org/10.1016/j.ymgme.2023.107677
dc.identifier.doi10.1016/j.ymgme.2023.107677
dc.identifier.issn1096-7192
dc.identifier.issn1096-7206
dc.identifier.issue3
dc.identifier.pmid37544048
dc.identifier.scopus2-s2.0-85166646035
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1016/j.ymgme.2023.107677
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11351
dc.identifier.volume140
dc.identifier.wos001054191700001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKendirci, Mustafa
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.relation.ispartofMolecular Genetics and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectArterial Stiffness
dc.subjectClassical Phenylketonuria
dc.subjectGlycemic Index
dc.subjectGlycemic Load
dc.subjectLeft Ventricular Mass Index
dc.subjectPediatric Age
dc.titleEvaluation of the effect of obesity, dietary glycemic index and metabolic profiles on the cardiovascular risk in children with classical phenylketonuria
dc.typeArticle

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