Clinicopathological significance of the proliferation markers Ki67, RacGAP1, and topoisomerase 2 alpha in breast cancer

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dc.authorid0000-0003-0128-6947
dc.contributor.authorŞahin, Sevinç
dc.contributor.authorIşık Gönül, İpek
dc.contributor.authorÇakır, Aslı
dc.contributor.authorSeçkin, Selda
dc.contributor.authorUluoğlu, Ömer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:57Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:57Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000382974300005
dc.descriptionPubMed ID: 27284123
dc.description.abstractObjectives. The aims of this study are to evaluate expressions of Ki67, RacGAP1 (MgcRacGAP) and topoisomerase 2 alpha (TOP2a), the markers related with cell proliferation that have been proposed to affect the prognosis in the literature and correlate the results with clinicopathological parameters of breast cancer patients. Methods. Ki67, RacGAP1, and TOP2a antibodies were applied immunohistochemically to the tissue micrarray blocks of 457 female breast cancer patients. The results were correlated with clinical, prognostic, histopathological features, and other immunohistochemical findings (estrogen receptor [ER], progesterone receptor [PR], HER2, cytokeratin [CK]5/6, CK14, epidermal growth factor receptor [EGFR] and vimentin), statistically. Results. Ki67 expression demonstrated direct correlation with TOP2a expression, mitotic count, tumor grade, geographic necrosis, basal-like phenotype. RacGAP1 expression was directly correlated with TOP2a expression, nipple invasion, and number of metastatic lymph nodes, and it was inversely correlated with PR expression. TOP2a expression was directly correlated with vimentin and Ki67 expressions, mitotic count, tumor grade, and geographic necrosis, and nipple invasion, and negatively correlated with ER and PR expressions. Higher TOP2a and Ki67 expressions were correlated with shorter overall survival. Higher TOP2a expression and RacGAP1 positivity were directly correlated with shorter disease-free survival. Conclusion. This study showed that the overexpressions of Ki67, RacGAP1, and TOP2a affect the prognosis adversely, thus to develop target therapies against RacGAP1 and TOP2a as well as using Ki67 as a part of routine pathology practice might be beneficial in breast cancer therapy and prediction of prognosis.
dc.description.sponsorshipBozok University Scientific Research Projects Unit [2014TF/A92]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported financially by Bozok University Scientific Research Projects Unit (Project No. 2014TF/A92).en_US
dc.identifier.citationŞahin, S., Işık Gönül, İ., Çakır, A., Seçkin, S. ve Uluoğlu, Ö. (2016). Clinicopathological significance of the proliferation markers Ki67, RacGAP1, and topoisomerase 2 alpha in breast cancer. International Journal Of Surgical Pathology, 24(7), 607-613. https://dx.doi.org/10.1177/1066896916653211
dc.identifier.doi10.1177/1066896916653211
dc.identifier.endpage613
dc.identifier.issn1066-8969
dc.identifier.issn1940-2465
dc.identifier.issue7
dc.identifier.scopusqualityQ2
dc.identifier.startpage607
dc.identifier.urihttps://dx.doi.org/10.1177/1066896916653211
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2861
dc.identifier.volume24
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofInternational Journal Of Surgical Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBreast Carcinoma
dc.subjectImmunohistochemistry
dc.subjectKi67
dc.subjectRacGAP1
dc.subjectTopoisomerase 2 Alpha
dc.titleClinicopathological significance of the proliferation markers Ki67, RacGAP1, and topoisomerase 2 alpha in breast cancer
dc.typeArticle

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