Vitamin D levels in patients with small and medium vessel vasculitis

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dc.authorid0000-0002-9927-3644
dc.contributor.authorKorkmaz, Fatma Nur
dc.contributor.authorÖzen, Gülşen
dc.contributor.authorÜnal, Ali Uğur
dc.contributor.authorOdabaşı, Aslı
dc.contributor.authorCan, Meryem
dc.contributor.authorAşıcıoğlu, Ebru
dc.contributor.authorTuğlular, Serhan
dc.contributor.authorDireskeneli, Haner
dc.date.accessioned2022-05-27T11:26:06Z
dc.date.available2022-05-27T11:26:06Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjectives: To determine the prevalence of vitamin D deficiency in patients with small and medium vessel systemic vasculitis.& nbsp;Methods: In this cross-sectional study, 25-hydroxy (OH) vitamin D3 levels were measured in adult patients with systemic small and medium vessel vasculitis including antineutrophil cytoplasmic antibody-associated vasculitis (AAV), cryoglobulinaemic vasculitis (CryV), IgA vasculitis (IgAV) and pol-yarteritis nodosa (PAN), and age- and sex-matched healthy subjects (HS) and patients with rheumatoid arthritis (RA) as control groups. 25OH vitamin D3 levels < 30 ng/ml and < 20 ng/ml were regarded as insufficiency and deficiency, respectively.& nbsp;Results: Fifty-seven patients (42 AAV, 2 CryV, 8 IgA vasculitis, 5 PAN) with systemic vasculitis, 101 HS, and 111 RA patients were included. The mean 25OH vitamin D3 level was 21.8 +/- 14.2 ng/mL in patients with vasculitis, 42.7 & nbsp;+/- 27.6 ng/mL in HS (p < .001) and 20.1 +/- 18.47 ng/mL in patients with RA (p = .54). Vitamin D insufficiency and deficiency were significantly higher in patients with systemic vasculitis compared to HS (75.4% vs 33.7%, p < .001; %50 vs 21.8%, p < .001, respectively). Vitamin D status was not different in patients with systemic vasculitis compared to RA. There was a negative correlation between vitamin D status and CRP levels (=-.364, p = .007). The multivariate logistic regression analysis showed that renal involvement was significantly associated with vitamin D deficiency/insufficiency in patients with vasculitis (OR 22.5 [95% CI 1.6-128.9].& nbsp;Conclusion: Vitamin D deficiency and insufficiency are more frequent in patients with systemic small and medium vessel vasculitis and RA than HS. Renal involvement is one of the factors associated with vitamin D deficiency/insufficiency in patients with vasculitis.
dc.description.abstractObjetivos: Determinar la prevalencia de la deficiencia de vitamina D en los pacientes con vasculitis sistémica de peque ?nos y medianos vasos. Métodos: En este estudio transversal se midieron los niveles de 25-hidroxivitamina D3 en pacientes adul- tos con vasculitis sistémica de peque ?nos y medianos vasos, incluyendo vasculitis asociada a anticuerpos anticitoplasma de neutrófilos (AAV), vasculitis crioglobulinémica (CryV), vasculitis IgA (IgAV) y poliar- teritis nodosa (PAN), y sujetos sanos pareados por edad y sexo (SS) y pacientes con artritis reumatoide (AR) como grupos control. Se consideraron insuficientes y deficientes los niveles de 25-hidroxivitamina D3 < 30 ng/ml y < 20 ng/ml, respectivamente. Resultados: Se incluyeron 57 pacientes (42 de AAV, 2 de CryV, 8 de vasculitis IgA y 5 de PAN) con vasculitis sistémica, 101 SS y 111 pacientes de AR. El nivel medio de 25-hidroxivitamina D3 fue de 21,8 ± 14,2 ng/ml en pacientes con vasculitis, 42,7 ± 27,6 ng/ml en SS (p < 0,001) y 20,1 ± 18,47 ng/ml en pacientes con AR (p = 0,54). La insuficiencia y deficiencia de vitamina D fueron significativamente más altas en los pacientes con vasculitis sistémica en comparación con los SS (75,4 vs. 33,7%; p < 0,001; 50 vs. 21,8%; p < 0,001, respectivamente). El estatus de vitamina D no fue diferente en los pacientes con vasculitis sistémica en comparación con AR. Existió una correlación negativa entre el estatus de vitamina D y los niveles de PCR = ?0,364; p = 0,007. El análisis de regresión logística multivariante reflejó que el compromiso renal estuvo significativamente asociado a la deficiencia/insuficiencia de vitamina D en los pacientes con vasculitis (OR: 22,5; IC 95%: 1,6-128,9). Conclusión: La insuficiencia y deficiencia de vitamina D son más frecuentes en los pacientes con vasculitis sistémica de peque ?nos y medianos vasos y AR que en los SS. El compromiso renal es uno de los factores asociados a la deficiencia/insuficiencia de vitamina D en los pacientes con vasculitis.
dc.identifier.citationKorkmaz, F. N., Özen, G., Ünal, A. U., Odabaşı, A., Can, M., Aşıcıoğlu, E. ... Direskeneli, H. (2022). Vitamin D levels in patients with small and medium vessel vasculitis. Reumatologia Clinica, 18(3), 141-146.
dc.identifier.endpage146
dc.identifier.issn1699-258X
dc.identifier.issn1885-1398
dc.identifier.issue3
dc.identifier.pmid35277211
dc.identifier.scopus2-s2.0-85099282264
dc.identifier.scopusqualityQ3
dc.identifier.startpage141
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9476
dc.identifier.volume18
dc.identifier.wos000793517400002en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCan, Meryem
dc.language.isoen
dc.publisherElsevier Espana Slu
dc.relation.ispartofReumatologia Clinicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectVasculitis
dc.subjectVitamin D
dc.subjectDeficiency
dc.subjectRheumatoid Arthritis
dc.subjectVasculitis
dc.subjectVitamina D
dc.subjectDeficiencia
dc.subjectArtritis Reumatoide
dc.titleVitamin D levels in patients with small and medium vessel vasculitis
dc.title.alternativeNiveles de vitamina D en pacientes con vasculitis de pequeños y vasos medianos
dc.typeArticle

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