Effects of various antibiotics alone or in combination with doripenem against Klebsiella pneumoniae strains isolated in an intensive care unit
| dc.authorid | 0000-0001-8022-7325 | |
| dc.contributor.author | Özbek Çelik, Berna | |
| dc.contributor.author | Mataracı-Kara, Emel | |
| dc.contributor.author | Yılmaz, Mesut | |
| dc.date.accessioned | 2020-06-23T08:42:50Z | |
| dc.date.available | 2020-06-23T08:42:50Z | |
| dc.date.issued | 2014 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı | |
| dc.description.abstract | Colistin, tigecycline, levofloxacin, tobramycin, and rifampin alone and in combination with doripenem were investigated for their in vitro activities and postantibiotic effects (PAEs) on Klebsiella pneumoniae. The in vitro activities of tested antibiotics in combination with doripenem were determined using a microbroth checkerboard technique. To determine the PAEs, K. pneumoniae strains in the logarithmic phase of growth were exposed for 1 h to antibiotics, alone and in combination. Recovery periods of test cultures were evaluated using viable counting after centrifugation. Colistin, tobramycin, and levofloxacin produced strong PAEs ranging from 2.71 to 4.23 h, from 1.31 to 3.82 h, and from 1.35 to 4.72, respectively, in a concentration-dependent manner. Tigecycline and rifampin displayed modest PAEs ranging from 1.18 h to 1.55 h and 0.92 to 1.19, respectively. Because it is a beta-lactam, PAEs were not exactly induced by doripenem (ranging from 0.10 to 0.18 h). In combination, doripenem scarcely changed the duration of PAE of each tested antibiotic alone. The findings of this study may have important implications for the timing of doses during K. pneumoniae therapy with tested antibiotics. | |
| dc.description.sponsorship | Istanbul University | en_US |
| dc.identifier.citation | Özbek Çelik, B., Mataracı-Kara, E. ve Yılmaz, M. (2014). Effects of various antibiotics alone or in combination with doripenem against Klebsiella pneumoniae strains isolated in an intensive care unit. BioMed Research International, 2014. https://dx.doi.org/10.1155/2014/397421 | |
| dc.identifier.doi | 10.1155/2014/397421 | |
| dc.identifier.issn | 2314-6133 | |
| dc.identifier.issn | 2314-6141 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/5288 | |
| dc.identifier.uri | https://dx.doi.org/10.1155/2014/397421 | |
| dc.identifier.volume | 2014 | |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Hindawi Publishing Corporation | |
| dc.relation.ispartof | BioMed Research International | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Doripenem | |
| dc.subject | Intensive Care Unit | |
| dc.subject | Klebsiella Pneumoniae | |
| dc.title | Effects of various antibiotics alone or in combination with doripenem against Klebsiella pneumoniae strains isolated in an intensive care unit | |
| dc.type | Article |
